Amplification of oxidative stress is present since the early stages of chronic kidney disease
(CKD), holding a key position in the pathogenesis of renal failure. Induction of renal pro …

Diabetic nephropathy (DN) is a serious kidney-related complication of both type 1 and type 2
diabetes mellitus (T1DM, T2DM) and the second major cause of end-stage kidney disease …

Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney
disease (CKD), suggesting intimate communication between the two types of cells …

Cellular senescence is associated with renal disease progression, and accelerated tubular
cell senescence promotes the pathogenesis of renal fibrosis. However, the underlying …

Podocyte injury is the major cause of proteinuria in primary glomerular diseases. Oxidative
stress has long been thought to play a role in triggering podocyte damage; however, the …

Podocytes are unique, highly specialized, terminally differentiated cells that are integral
components of the kidney glomerular filtration barrier. Podocytes are vulnerable to a variety …

The Wnt/β-catenin signaling cascade is an evolutionarily conserved, highly complex
pathway that is known to be involved in kidney injury and repair after a wide variety of …

Wnt signal cascade is an evolutionarily conserved, developmental pathway that regulates
embryogenesis, injury repair, and pathogenesis of human diseases. It is well established …

Intracellular proteins continuously turn over by degradation and synthesis in all organ
tissues. Owing to its irreversible nature, protein degradation is a highly selective process to …

Klotho is a membrane-bound protein predominantly expressed in the kidney, where it acts
as a permissive co-receptor for Fibroblast Growth Factor 23. In its shed form, Klotho exerts …