Sphingolipids have emerged as bioactive lipids involved in the regulation of many
physiological and pathological processes. In the retina, they have been established to …

GBA mutations are to date the most common genetic risk factor for Parkinson's disease. The
GBA gene encodes the lysomal hydrolase glucocerebrosidase. Whilst bi-allelic GBA …

Background Gaucher disease (GD) presents with a range of signs and symptoms.
Physicians can fail to recognise the early stages of GD owing to a lack of disease …

Many sphingolipids have key functions in the regulation of crucial cellular processes.
Ceramide (Cer) and sphingosine (Sph) induce growth arrest and cell death in multiple …

Gaucher disease (GD) results from a deficiency of glucocerebrosidase activity and the
subsequent accumulation of the enzyme's metabolites, principally glucosylsphingosine and …

Sphingolipids are bioactive molecules associated with oxidative stress, inflammation, and
neurodegenerative diseases, but poorly studied in the context of age-related macular …

Retinal degenerations (RD) are a complex heterogeneous group of diseases in which
retinal photoreceptors and the supporting retinal pigment epithelial cells die irreversibly …

Abstract Treatment of glaucoma, the leading cause of irreversible blindness, remains
challenging. The apoptotic loss of retinal ganglion cells (RGCs) in glaucoma is the …

Gaucher disease is an autosomal recessive lysosomal storage disorder caused by
mutations in the gene GBA1, which encodes the lysosomal protein glucocerebrosidase …

Purpose: Sphingolipid (SL) research reached a peak in the past years. Yet this positive trend
was not evident for eye research as the relative number of studies centered on SLs is …