Acute and chronic kidney disease encompasses a complex set of diseases that can both
lead to, and result from, cancer. In particular, kidney disease can arise from the use of …

Primary central nervous system lymphoma (PCNSL) has long been associated with an
inferior prognosis compared to other aggressive non-Hodgkin's lymphomas (NHLs) …

Context: Methotrexate (MTX) is an anti-folate drug that has been utilized in both malignant
and chronic inflammatory conditions. Doctors are often concerned with a potential adverse …

Background Acute kidney injury complicating high‐dose methotrexate (HDMTX) therapy
increases the risk for severe mucositis, myelosuppression, and death. It is unclear whether …

Purpose Glucarpidase (Voraxaze) is used to treat methotrexate (Mtx) toxicity in patients with
delayed Mtx clearance due to impaired renal function. We examine hospital length of stay …

The aims of this study were to characterize the incidence and outcomes of severe toxicities
following the administration of high-dose methotrexate (HD-MTX;≥ 1 g/m2). Among the 468 …

Kidney-related adverse drug effects from chemotherapeutic agents can cause acute kidney
injury that may influence cancer treatment and patient outcomes. Many current …

Methotrexate (MTX) toxicity varies depending on factors such as dosing frequency (acute or
repeated), dosage (low or high) and the administration route (oral, parenteral or intrathecal) …

Therapeutic drug monitoring (TDM), the measurement of medications in whole blood, serum,
or plasma, plays a vital part in the management of patient's prescribed drugs with narrow …

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