Membrane proteins play critical physiological roles in all organisms, from ion transport and
signal transduction to multidrug resistance. Elucidating their 3D structures is essential for …

To study integral membrane proteins, one has to extract them from the membrane—the step
that is typically achieved by the application of detergents. In this mini-review, we summarize …

Type-A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of rapid
inhibitory synaptic transmission in the human brain. A decline in GABAAR signalling triggers …

TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by
multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the …

Type A γ-aminobutyric acid receptors (GABAARs) are the principal mediators of inhibitory
neurotransmission in the human brain. Endogenous neurosteroids interact with GABAARs to …

Abstract The field of Membrane Protein Structural Biology has grown significantly since its
first landmark in 1985 with the first three-dimensional atomic resolution structure of a …

Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …

Protein crystallization has been known since 1840 and can prove to be straightforward but,
in most cases, it constitutes a real bottleneck. This stimulated the birth of the …

Surfactants find applications in almost every chemical industry, such as household and
industrial cleaning, paper, inks, agrochemicals, and personal care or pharmaceuticals …

Metal ions are essential for all forms of life. In prokaryotes, ATP-binding cassette (ABC)
permeases serve as the primary import pathway for many micronutrients including the first …