Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …

Syndecans are type I transmembrane proteins having a core protein modified with
glycosaminoglycan chains, most commonly heparan sulphate. They are an ancient group of …

Laminins, heterotrimers composed of α, β, and γ chains, are multifunctional glycoproteins
present in basement membranes. Laminins, the most important component of basement …

Summary Background Proteoglycans (PGs) are known to play key roles in many cellular
signalling pathways involved in hair follicle biology. Although some PG core proteins have …

Extracellular matrix (ECM) and matrix receptors are intimately involved in most biological
processes. The ECM plays fundamental developmental and physiological roles in health …

Extracellular signals are transmitted to cells through two classes of cell-surface receptors:
signaling receptors that directly transduce signals and signaling co-receptors that bind …

In a genetic screen for regulators of synaptic morphology, we identified the single
Caenorhabditis elegans flamingo-like cadherin fmi-1. The fmi-1 mutants exhibit defective …

Cell protrusions contribute to cell motility and migration by mediating the outward extension
and initial adhesion of cell edges. In many cells, these extensions are supported by actin …

Proteoglycans and glycosaminoglycans modulate numerous cellular processes relevant to
tumour progression, including cell proliferation, cell-matrix interactions, cell motility and …

Lysyl oxidase-like 3 (LOXL3), belonging to the lysyl oxidase family, is responsible for the
crosslinking in collagen or elastin. The cellular localization of LOXL3 is in the extracellular …