▪ Abstract Research in the past decade has revealed that many cytosolic proteins are
recruited to different cellular membranes to form protein-protein and lipid-protein interactions …

Phosphoinositide (PI) lipids are essential components of eukaryotic cell membranes. They
are produced by mono-, bis-and trisphosphorylation of the inositol headgroup of …

Retromer is a multi-protein complex that recycles transmembrane cargo from endosomes to
the trans-Golgi network and the plasma membrane. Defects in retromer impair various …

The late Golgi compartment is a major protein sorting station in the cell. Secreted proteins,
cell surface proteins, and proteins destined for endosomes or lysosomes must be sorted …

Macroautophagy is essential to cell survival during starvation and proceeds by the growth of
a double-membraned phagophore, which engulfs cytosol and other substrates. The …

Pichia pastoris and Hanseula polymorpha are methylotrophic yeasts capable of utilizing
methanol, as a sole source of carbon and energy. Growth of these yeast species on …

Retromer is an evolutionarily conserved protein complex composed of the VPS26, VPS29,
and VPS35 proteins that selects and packages cargo proteins into transport carriers that …

Phosphoinositides (PIs) are phosphorylated derivatives of phosphatidylinositol (PtdIns) that
regulate many cellular and physiological processes. Most PIs act by serving as membrane …

Abstract Drosophila Wingless (Wg) acts as a morphogen during development. Wg secretion
is controlled by a seven-pass transmembrane cargo Wntless (Wls). We have recently …

Targeting and retention of resident integral membrane proteins of the Golgi apparatus
underly the function of the Golgi in glycoprotein and glycolipid processing and sorting. In …