Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer
Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …
Heat-shock proteins: chaperoning DNA repair
L Dubrez, S Causse, N Borges Bonan, B Dumétier… - Oncogene, 2020 - nature.com
Cells are repeatedly exposed to environmental or endogenous stresses that can alter
normal cell behavior and increase cell vulnerability. In order to ensure tissue integrity and …
normal cell behavior and increase cell vulnerability. In order to ensure tissue integrity and …
Biofilm Producing Salmonella Typhi: Chronic Colonization and Development of Gallbladder Cancer
EG Di Domenico, I Cavallo, M Pontone, L Toma… - International journal of …, 2017 - mdpi.com
Salmonella enterica subspecies enterica serovar Typhi is the aetiological agent of typhoid or
enteric fever. In a subset of individuals, S. Typhi colonizes the gallbladder causing an …
enteric fever. In a subset of individuals, S. Typhi colonizes the gallbladder causing an …
Targeting oxidatively induced DNA damage response in cancer: opportunities for novel cancer therapies
P Davalli, G Marverti, A Lauriola… - Oxidative medicine and …, 2018 - Wiley Online Library
Cancer is a death cause in economically developed countries that results growing also in
developing countries. Improved outcome through targeted interventions faces the scarce …
developing countries. Improved outcome through targeted interventions faces the scarce …
Crosstalk between Phosphoinositide 3‐kinase/Akt signaling pathway with DNA damage response and oxidative stress in cancer
Abstract The phosphatidylinositol 3‐kinases (PI3K)/Akt signaling pathway is one of the well‐
characterized and most important signaling pathways activated in response to DNA …
characterized and most important signaling pathways activated in response to DNA …
The cytolethal distending toxin contributes to microbial virulence and disease pathogenesis by acting as a tri-perditious toxin
MD Scuron, K Boesze-Battaglia, M Dlakić… - Frontiers in cellular …, 2016 - frontiersin.org
This review summarizes the current status and recent advances in our understanding of the
role that the cytolethal distending toxin (Cdt) plays as a virulence factor in promoting disease …
role that the cytolethal distending toxin (Cdt) plays as a virulence factor in promoting disease …
Prostate cancer-associated SPOP mutations lead to genomic instability through disruption of the SPOP–HIPK2 axis
X Jin, S Qing, Q Li, H Zhuang, L Shen, J Li… - Nucleic Acids …, 2021 - academic.oup.com
Speckle-type Poz protein (SPOP), an E3 ubiquitin ligase adaptor, is the most frequently
mutated gene in prostate cancer. The SPOP-mutated subtype of prostate cancer shows high …
mutated gene in prostate cancer. The SPOP-mutated subtype of prostate cancer shows high …
DUBbing cancer: deubiquitylating enzymes involved in epigenetics, DNA damage and the cell cycle as therapeutic targets
A Pinto-Fernandez, BM Kessler - Frontiers in genetics, 2016 - frontiersin.org
Controlling cell proliferation is one of the hallmarks of cancer. A number of critical
checkpoints ascertain progression through the different stages of the cell cycle, which can …
checkpoints ascertain progression through the different stages of the cell cycle, which can …
MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity
G Holmgren, J Synnergren, CX Andersson, A Lindahl… - Toxicology in Vitro, 2016 - Elsevier
Anthracyclines, such as doxorubicin, are well-established, highly efficient anti-neoplastic
drugs used for treatment of a variety of cancers, including solid tumors, leukemia …
drugs used for treatment of a variety of cancers, including solid tumors, leukemia …
DNA damage responsive miR-33b-3p promoted lung cancer cells survival and cisplatin resistance by targeting p21WAF1/CIP1
S Xu, H Huang, Y Chen, Y Deng, B Zhang, X Xiong… - Cell Cycle, 2016 - Taylor & Francis
Cisplatin is the most potent and widespread used chemotherapy drug for lung cancer
treatment. However, the development of resistance to cisplatin is a major obstacle in clinical …
treatment. However, the development of resistance to cisplatin is a major obstacle in clinical …