Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …

Cells are repeatedly exposed to environmental or endogenous stresses that can alter
normal cell behavior and increase cell vulnerability. In order to ensure tissue integrity and …

Salmonella enterica subspecies enterica serovar Typhi is the aetiological agent of typhoid or
enteric fever. In a subset of individuals, S. Typhi colonizes the gallbladder causing an …

Cancer is a death cause in economically developed countries that results growing also in
developing countries. Improved outcome through targeted interventions faces the scarce …

Abstract The phosphatidylinositol 3‐kinases (PI3K)/Akt signaling pathway is one of the well‐
characterized and most important signaling pathways activated in response to DNA …

This review summarizes the current status and recent advances in our understanding of the
role that the cytolethal distending toxin (Cdt) plays as a virulence factor in promoting disease …

Speckle-type Poz protein (SPOP), an E3 ubiquitin ligase adaptor, is the most frequently
mutated gene in prostate cancer. The SPOP-mutated subtype of prostate cancer shows high …

Controlling cell proliferation is one of the hallmarks of cancer. A number of critical
checkpoints ascertain progression through the different stages of the cell cycle, which can …

Anthracyclines, such as doxorubicin, are well-established, highly efficient anti-neoplastic
drugs used for treatment of a variety of cancers, including solid tumors, leukemia …

Cisplatin is the most potent and widespread used chemotherapy drug for lung cancer
treatment. However, the development of resistance to cisplatin is a major obstacle in clinical …