Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis,
resulting in hyperglycaemia. Although current diabetes treatments have exhibited some …

Insulin resistance is common in individuals with obesity or type 2 diabetes (T2D), in which
circulating insulin levels are frequently increased. Recent epidemiological and clinical …

Diabetes mellitus is a chronic disease that leads to complications including heart disease,
stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target …

Diabetes mellitus is a major health concern, affecting more than 5% of the population. Here
we describe a potential novel therapeutic agent for this disease, FGF-21, which was …

Metformin is a first-line therapeutic option for the treatment of type 2 diabetes, even though
its underlying mechanisms of action are relatively unclear,,,,,. Metformin lowers blood …

Circulating insulin inhibits endogenous glucose production. Here we report that bidirectional
changes in hypothalamic insulin signaling affect glucose production. The infusion of either …

The hallmark of type 1 diabetes is specific destruction of pancreatic islet β-cells. Apoptosis of
β-cells may be crucial at several points during disease progression, initiating leukocyte …

The serine/threonine kinase Akt/PKB plays key roles in the regulation of cell growth, survival,
and metabolism. It remains unclear, however, whether the functions of individual Akt/PKB …

In this study, we defined the role of peroxisome proliferator-activated receptor β/δ (PPARδ)
in metabolic homeostasis by using subtype selective agonists. Analysis of rat L6 myotubes …

Glucose flux through the hexosamine biosynthetic pathway leads to the post-translational
modification of cytoplasmic and nuclear proteins by O-linked β-N-acetylglucosamine (O …