Progressive multifocal leukoencephalopathy (PML) is a devastating CNS infection caused
by JC virus (JCV), a polyomavirus that commonly establishes persistent, asymptomatic …

Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal
central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which …

The immune reconstitution inflammatory syndrome (IRIS) is a frequent early complication of
antiretroviral therapy (ART) in patients with advanced HIV. Because there is no confirmatory …

Progressive multifocal leukoencephalopathy (PML) is a disease of the central nervous
system (CNS) with destructive infection of oligodendrocytes by JC virus. PML belongs to the …

John Cunningham virus (JCV) is a member of the Polyomaviridae family. It was first isolated
from the brain of a patient with Hodgkin disease in 1971, and since then the etiological …

JCV is a small (∼ 45 nm), non-enveloped, circular, double-stranded DNA genome,
arranged in 72 viral capsomeres with icosahedral symmetry (Tan et al., 2009a). The genome …

Progressive multifocal leukoencephalopathy (PML) is a rare, but serious, complication
encountered in patients treated with a select number of disease-modifying therapies (DMTs) …

In kidney transplant patients with BK polyomavirus (BKPyV) nephropathy, viral variants arise
bearing rearranged noncoding control regions (rr-NCCRs) that increase viral early gene …

The fatal CNS demyelinating disease, progressive multifocal leukoencephalopathy (PML), is
rare and appears to occur almost always as a consequence of immune dysfunction. Thus, it …

JC polyomavirus (JCPyV) is the causative agent of the fatal, incurable, neurological disease,
progressive multifocal leukoencephalopathy (PML). The virus is present in most of the adult …