Alcohol dehydrogenases, aldehyde dehydrogenases, and alcohol use disorders: a critical review
HJ Edenberg, JN McClintick - Alcoholism: Clinical and …, 2018 - Wiley Online Library
Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes
contribute to the risk, as does the environment. Although the total genetic contribution to risk …
contribute to the risk, as does the environment. Although the total genetic contribution to risk …
Genetic architectures of psychiatric disorders: the emerging picture and its implications
Psychiatric disorders are among the most intractable enigmas in medicine. In the past 5
years, there has been unprecedented progress on the genetics of many of these conditions …
years, there has been unprecedented progress on the genetics of many of these conditions …
[HTML][HTML] Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations
Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately
heritable traits. We conduct genome-wide association studies of these traits using …
heritable traits. We conduct genome-wide association studies of these traits using …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak, V Leppa… - Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
Genome-wide association study meta-analysis of the alcohol use disorders identification test (AUDIT) in two population-based cohorts
S Sanchez-Roige, AA Palmer… - American Journal of …, 2019 - Am Psychiatric Assoc
Objective: Alcohol use disorders are common conditions that have enormous social and
economic consequences. Genome-wide association analyses were performed to identify …
economic consequences. Genome-wide association analyses were performed to identify …
[HTML][HTML] Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N= 112 117)
Alcohol consumption has been linked to over 200 diseases and is responsible for over 5%
of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for …
of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for …
[HTML][HTML] The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
Abstract The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA)
Consortium is a collaborative network of researchers working together on a range of large …
Consortium is a collaborative network of researchers working together on a range of large …
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We
carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …
carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
Excessive alcohol consumption is a major public health problem worldwide. Although
drinking habits are known to be inherited, few genes have been identified that are robustly …
drinking habits are known to be inherited, few genes have been identified that are robustly …
Genome-wide association study of alcohol dependence: significant findings in African-and European-Americans including novel risk loci
We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-
American (AA) populations, with replication in independent samples of EAs, AAs and …
American (AA) populations, with replication in independent samples of EAs, AAs and …