Neurodegenerative diseases are caused by the progressive loss of specific neurons. The
exact mechanisms of action of these diseases are unknown, and many studies have focused …

Inflammation, although necessary to fight infections, becomes a threat when it exceeds the
capability of the immune system to control it. In addition, inflammation is a cause and/or …

Mitochondrial dysfunction and the loss of mitophagy, aimed at recycling irreversibly
damaged organelles, contribute to the onset of amyotrophic lateral sclerosis (ALS), a fatal …

Background One of the factors that affect the progression of melanoma is the tumor
microenvironment, which consists of cellular elements, extracellular matrix, acidification, and …

Methylmercury (MeHg+) is a known neurotoxin that causes progressive motor neuron
degeneration in the central nervous system. Axonal degeneration, oligodendrocyte …

Hyperphosphorylated TAR DNA-binding protein 43 (TDP-43) aggregates in the cytoplasm of
neurons is the neuropathological hallmark of amyotrophic lateral sclerosis (ALS) and a …

Spinal cord injury (SCI) is a severe neurological disorder and the molecular mechanisms
leading to its poor prognosis remain to be elucidated. S100A1, a mediator of Ca2+ handling …

Amyotrophic lateral sclerosis (ALS) is a paralytic disease that damages the brain and spinal
cord motor neurons. Several clinical and preclinical studies have found that methylmercury …

Diabetic neuropathy (DN) is a neurodegenerative disorder that is primarily characterized by
distal sensory loss, reduced mobility, and foot ulcers that may potentially lead to amputation …

Background As a leading cause of mortality and long-term disability, acute ischemic stroke
can produce far-reaching pathophysiological consequences. Accumulating evidence has …