SARS-CoV-2 Omicron BA. 1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals
How infection by a viral variant showing antigenic drift impacts a preformed mature human
memory B cell (MBC) repertoire remains an open question. Here, we studied the MBC …
memory B cell (MBC) repertoire remains an open question. Here, we studied the MBC …
Challenges and progress in designing broad-spectrum vaccines against rapidly mutating viruses
Viruses evolve to evade prior immunity, causing significant disease burden. Vaccine
effectiveness deteriorates as pathogens mutate, requiring redesign. This is a problem that …
effectiveness deteriorates as pathogens mutate, requiring redesign. This is a problem that …
IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data
In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …
associated with each T-and B-cell receptor sequence is a crucial step. This process is highly …
Predicting adaptive immune receptor specificities by machine learning is a data generation problem
Determining the specificity of adaptive immune receptors—B cell receptors (BCRs), their
secreted form antibodies, and T cell receptors (TCRs)—is critical for understanding immune …
secreted form antibodies, and T cell receptors (TCRs)—is critical for understanding immune …
Novel omicron variants enhance anchored recognition of TMEM106B: a new pathway for SARS-CoV-2 cellular invasion
The recent discovery that TMEM106B serves as a receptor mediating ACE2-independent
SARS-CoV-2 entry into cells deserves attention, especially in the background of the frequent …
SARS-CoV-2 entry into cells deserves attention, especially in the background of the frequent …
COVID-19-related age profiles for SARS-CoV-2 variants in England and Wales and States of the USA (2020 to 2022): Impact on all-cause mortality
RP Jones, A Ponomarenko - Infectious Disease Reports, 2023 - mdpi.com
Since 2020, COVID-19 has caused serious mortality around the world. Given the ambiguity
in establishing COVID-19 as the direct cause of death, we first investigate the effects of age …
in establishing COVID-19 as the direct cause of death, we first investigate the effects of age …
Adaptive immune receptor genotyping using the corecount program
S Narang, M Kaduk, M Chernyshev… - Frontiers in …, 2023 - frontiersin.org
We present a new Rep-Seq analysis tool called corecount, for analyzing genotypic variation
in immunoglobulin (IG) and T cell receptor (TCR) genes. corecount is highly efficient at …
in immunoglobulin (IG) and T cell receptor (TCR) genes. corecount is highly efficient at …
Multimodal Mass Spectrometry Identifies a Conserved Protective Epitope in S. pyogenes Streptolysin O
D Tang, C Gueto-Tettay, E Hjortswang… - Analytical …, 2024 - ACS Publications
An important element of antibody-guided vaccine design is the use of neutralizing or
opsonic monoclonal antibodies to define protective epitopes in their native three …
opsonic monoclonal antibodies to define protective epitopes in their native three …
Real-time estimation of immunological responses against emerging SARS-CoV-2 variants in the UK: a mathematical modelling study
TW Russell, H Townsley, J Hellewell… - The Lancet Infectious …, 2024 - thelancet.com
Background The emergence of SARS-CoV-2 variants and COVID-19 vaccination have
resulted in complex exposure histories. Rapid assessment of the effects of these exposures …
resulted in complex exposure histories. Rapid assessment of the effects of these exposures …
Widespread impact of immunoglobulin V-gene allelic polymorphisms on antibody reactivity
The ability of the human immune system to generate antibodies to any given antigen can be
strongly influenced by immunoglobulin V-gene allelic polymorphisms. However, previous …
strongly influenced by immunoglobulin V-gene allelic polymorphisms. However, previous …