The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

Chimeric antigen receptor (CAR) T cell therapies have demonstrated remarkable efficacy for
the treatment of hematological malignancies. However, in patients with solid tumors …

The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells
(MSCs) potentially improves clinical symptoms, but the underlying mechanism remains …

Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of
hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver …

COVID‐19 is a pandemic disease caused by the new coronavirus SARS‐CoV‐2 that mostly
affects the respiratory system. The consequent inflammation is not able to clear viruses. The …

Risks of tumor recurrence after surgical resection have been known for decades, but the
mechanisms underlying treatment failures remain poorly understood. Neutrophils, first-line …

The receptor for advanced glycation end-products (RAGE) is a multiligand pattern
recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Our immune system is based on the close collaboration of the innate and adaptive immune
systems for the rapid detection of any threats to the host. Recognition of pathogen-derived …

Background High-mobility group box 1 (HMGB1) is a multifunctional redox-sensitive protein
involved in various intracellular (eg, chromatin remodeling, transcription, autophagy) and …