Astrocytes are the most populous glial cells in the central nervous system (CNS). They are
essential to CNS physiology and play important roles in the maintenance of homeostasis …

Glioblastoma (GBM) is the most malignant brain tumor and accounts for most adult brain
tumors. Current available treatment options for GBM are multimodal, which include surgical …

Despite recent advances in cancer immunotherapy, certain tumor types, such as
Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti …

Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal
diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic …

Chitinase-3–like protein 1 (CHI3L1) is primarily secreted by activated astrocytes in the brain
and is known as a reliable biomarker for inflammatory central nervous system (CNS) …

Abstract Chitinase‐3‐like protein 1 (CHI3L1/YKL‐40) has long been known as a biomarker
for early detection of neuroinflammation and disease diagnosis of Alzheimer's disease (AD) …

The brain is unique and the most complex organ of the body, containing neurons and
several types of glial cells of different origins and properties that protect and ensure normal …

Brain cancers carry bleak prognoses, with therapeutic advances helping only a minority of
patients over the past decade. The brain tumour microenvironment (TME) is highly …

Abstract Chitinase‐3‐like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its
ability to regulate multiple biological processes, such as the inflammatory response and …

Abstract Chitinase 3–like 1 (Chi3l1) is a secreted protein that is highly expressed in
glioblastoma. Here, we show that Chi3l1 alters the state of glioma stem cells (GSC) to …