[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Significance of angiotensin 1–7 coupling with MAS1 receptor and other GPCRs to the renin‐angiotensin system: IUPHAR Review 22

SS Karnik, KD Singh, K Tirupula… - British journal of …, 2017 - Wiley Online Library
Angiotensins are a group of hormonal peptides and include angiotensin II and angiotensin 1–
7 produced by the renin angiotensin system. The biology, pharmacology and biochemistry of …

Angiotensin-(1–7) attenuates angiotensin II-induced cardiac hypertrophy via a Sirt3-dependent mechanism

L Guo, A Yin, Q Zhang, T Zhong… - American Journal of …, 2017 - journals.physiology.org
The objectives of the present study were to investigate the effect of ANG-(1–7) on the
development of cardiac hypertrophy and to identify the intracellular mechanism underlying …

Angiotensin-(1-7): translational avenues in cardiovascular control

D Medina, AC Arnold - American journal of hypertension, 2019 - academic.oup.com
Despite decades of research and numerous treatment approaches, hypertension and
cardiovascular disease remain leading global public health problems. A major contributor to …

RhoA-Rho associated kinase signaling leads to renin-angiotensin system imbalance and angiotensin converting enzyme 2 has a protective role in acute pulmonary …

X Xu, L Shi, X Ma, H Su, G Ma, X Wu, K Ying… - Thrombosis research, 2019 - Elsevier
Introduction Acute pulmonary embolism (APE) is a cardiovascular disease with high
morbidity and mortality. Although the anatomical obstruction of the pulmonary vascular bed …

Local angiotensin-(1–7) administration improves microvascular endothelial function in women who have had preeclampsia

AE Stanhewicz, LM Alexander - American Journal of …, 2020 - journals.physiology.org
Despite remission of clinical symptoms postpartum, women who have had preeclampsia
demonstrate microvascular endothelial dysfunction, mediated in part by increased sensitivity …

Genetic interference with endothelial PPAR-γ (peroxisome proliferator–activated receptor-γ) augments effects of angiotensin II while impairing responses to …

TM De Silva, C Hu, DA Kinzenbaw, ML Modrick… - …, 2017 - Am Heart Assoc
Pharmacological activation of PPAR-γ (peroxisome proliferator–activated receptor-γ)
protects the vasculature. Much less is known on the cell-specific impact of PPAR-γ when …

Angiotensin-(1–7) Restores Microcirculation Profiles in Acute Pancreatitis: Secret of Telomerase Reverse Transcriptase

X Wang, T Cui, T Zhang, W Hu, R Liu, C Yin - Pancreas, 2022 - journals.lww.com
Objectives The aim of this study was to investigate whether angiotensin (Ang)-(1–7)–
mediated restoration of pancreatic microcirculation profiles and endothelial injury is …

Effects of angiotensin-(1–7) and angiotensin II on vascular tone in human cirrhotic splanchnic vessels

S Casey, C Herath, I Rajapaksha, R Jones, P Angus - Peptides, 2018 - Elsevier
Evidence suggests that the renin angiotensin system (RAS) may play a role in the
pathological splanchnic vasodilatation that leads to a hyperdynamic circulation in cirrhosis …

Angiotensin II‐induced endothelial dysfunction: Impact of sex, genetic background, and rho kinase

DA Kinzenbaw, L Langmack, FM Faraci - Physiological reports, 2022 - Wiley Online Library
The renin‐angiotensin system (RAS) contributes to vascular disease with multiple
cardiovascular risk factors including hypertension. As a major effector within the RAS …