Vitamin B12, folate, and the methionine remethylation cycle—biochemistry, pathways, and regulation
DS Froese, B Fowler… - Journal of inherited …, 2019 - Wiley Online Library
Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …
Scaling single-cell genomics from phenomenology to mechanism
A Tanay, A Regev - Nature, 2017 - nature.com
Three of the most fundamental questions in biology are how individual cells differentiate to
form tissues, how tissues function in a coordinated and flexible fashion and which gene …
form tissues, how tissues function in a coordinated and flexible fashion and which gene …
The human cell atlas
A Regev, SA Teichmann, ES Lander, I Amit, C Benoist… - elife, 2017 - elifesciences.org
The recent advent of methods for high-throughput single-cell molecular profiling has
catalyzed a growing sense in the scientific community that the time is ripe to complete the …
catalyzed a growing sense in the scientific community that the time is ripe to complete the …
A comprehensive transcriptional map of primate brain development
The transcriptional underpinnings of brain development remain poorly understood,
particularly in humans and closely related non-human primates. We describe a high …
particularly in humans and closely related non-human primates. We describe a high …
[HTML][HTML] Computational assignment of cell-cycle stage from single-cell transcriptome data
The transcriptome of single cells can reveal important information about cellular states and
heterogeneity within populations of cells. Recently, single-cell RNA-sequencing has …
heterogeneity within populations of cells. Recently, single-cell RNA-sequencing has …
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes
The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …
de-regulation of this timing promotes the formation of cancer and leads to defects during …
Computational deconvolution of transcriptomics data from mixed cell populations
Gene expression analyses of bulk tissues often ignore cell type composition as an important
confounding factor, resulting in a loss of signal from lowly abundant cell types. In this review …
confounding factor, resulting in a loss of signal from lowly abundant cell types. In this review …
Studying and modelling dynamic biological processes using time-series gene expression data
Biological processes are often dynamic, thus researchers must monitor their activity at
multiple time points. The most abundant source of information regarding such dynamic …
multiple time points. The most abundant source of information regarding such dynamic …
Droplet-based method and apparatus for composite single-cell nucleic acid analysis
A Regev, EZ Macosko, SA McCarroll… - US Patent …, 2023 - Google Patents
US11597964B2 - Droplet-based method and apparatus for composite single-cell nucleic acid
analysis - Google Patents US11597964B2 - Droplet-based method and apparatus for composite …
analysis - Google Patents US11597964B2 - Droplet-based method and apparatus for composite …
Three-dimensional reconstruction of protein networks provides insight into human genetic disease
X Wang, X Wei, B Thijssen, J Das, SM Lipkin… - Nature …, 2012 - nature.com
To better understand the molecular mechanisms and genetic basis of human disease, we
systematically examine relationships between 3,949 genes, 62,663 mutations and 3,453 …
systematically examine relationships between 3,949 genes, 62,663 mutations and 3,453 …