Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …

Three of the most fundamental questions in biology are how individual cells differentiate to
form tissues, how tissues function in a coordinated and flexible fashion and which gene …

The recent advent of methods for high-throughput single-cell molecular profiling has
catalyzed a growing sense in the scientific community that the time is ripe to complete the …

The transcriptional underpinnings of brain development remain poorly understood,
particularly in humans and closely related non-human primates. We describe a high …

The transcriptome of single cells can reveal important information about cellular states and
heterogeneity within populations of cells. Recently, single-cell RNA-sequencing has …

The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …

Gene expression analyses of bulk tissues often ignore cell type composition as an important
confounding factor, resulting in a loss of signal from lowly abundant cell types. In this review …

Biological processes are often dynamic, thus researchers must monitor their activity at
multiple time points. The most abundant source of information regarding such dynamic …

US11597964B2 - Droplet-based method and apparatus for composite single-cell nucleic acid
analysis - Google Patents US11597964B2 - Droplet-based method and apparatus for composite …

To better understand the molecular mechanisms and genetic basis of human disease, we
systematically examine relationships between 3,949 genes, 62,663 mutations and 3,453 …