Malaria in pregnancy: pathogenesis and immunity
Understanding of the biological basis for susceptibility to malaria in pregnancy was recently
advanced by the discovery that erythrocytes infected with Plasmodium falciparum …
advanced by the discovery that erythrocytes infected with Plasmodium falciparum …
Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates
Understanding the targets and mechanisms of human immunity to malaria caused by
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …
Genome sequence of the human malaria parasite Plasmodium falciparum
The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of
malaria, and kills more than one million African children annually. Here we report an …
malaria, and kills more than one million African children annually. Here we report an …
Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A‐adhering Plasmodium falciparum involved in pregnancy‐associated …
Cytoadhesion of infected red blood cells (iRBC) is mediated through parasite‐encoded,
clonally variant surface antigens (VSA) and is a central process in the pathogenesis of …
clonally variant surface antigens (VSA) and is a central process in the pathogenesis of …
Evidence for the involvement of VAR2CSA in pregnancy-associated malaria
In Plasmodium falciparum–endemic areas, pregnancy-associated malaria (PAM) is an
important health problem. The condition is precipitated by accumulation of parasite-infected …
important health problem. The condition is precipitated by accumulation of parasite-infected …
Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions
T Lavstsen, A Salanti, ATR Jensen, DE Arnot… - Malaria journal, 2003 - Springer
Background The variant surface antigen family Plasmodium falciparum erythrocyte
membrane protein-1 (PfEMP1) is an important target for protective immunity and is …
membrane protein-1 (PfEMP1) is an important target for protective immunity and is …
[HTML][HTML] A family affair: var genes, PfEMP1 binding, and malaria disease
SM Kraemer, JD Smith - Current opinion in microbiology, 2006 - Elsevier
An immunovariant adhesion protein family in Plasmodium falciparum named erythrocyte
membrane protein 1 (PfEMP1), encoded by var genes, is responsible for both antigenic …
membrane protein 1 (PfEMP1), encoded by var genes, is responsible for both antigenic …
Plasmodium falciparum Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A var Genes
ATR Jensen, P Magistrado, S Sharp… - The Journal of …, 2004 - rupress.org
Parasite-encoded variant surface antigens (VSAs) like the var gene–encoded Plasmodium
falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic …
falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic …
Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria
T Staalsoe, CE Shulman, JN Bulmer, K Kawuondo… - The Lancet, 2004 - thelancet.com
Background Pregnancy-associated malaria caused by Plasmodium falciparum adherence to
chondroitin sulfate A in the placental intervillous space is a major cause of low birthweight …
chondroitin sulfate A in the placental intervillous space is a major cause of low birthweight …
Widespread functional specialization of Plasmodium falciparum erythrocyte membrane protein 1 family members to bind CD36 analysed across a parasite genome
BA Robinson, TL Welch, JD Smith - Molecular microbiology, 2003 - Wiley Online Library
Plasmodium falciparum‐infected erythrocytes sequester from blood circulation by binding
host endothelium. A large family of variant proteins mediates cytoadherence and their …
host endothelium. A large family of variant proteins mediates cytoadherence and their …