Hepatocytes form a crucially important cell layer that separates sinusoidal blood from the
canalicular bile. They have a uniquely organized polarity with a basal membrane facing liver …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

The mechanisms that allow the body to sense iron levels in order to maintain iron
homeostasis are unknown. Patients with the most common form of hereditary iron overload …

Junctional adhesion molecules (JAMs) comprise a small subfamily of the immunoglobulin
superfamily of adhesion receptors with a multitude of physiological functions in vertebrate …

The primary reservoir for hepatitis C virus (HCV) replication is believed to be hepatocytes,
which are highly polarized with tight junctions (TJ) separating their basolateral and apical …

Post-translational modifications (PTMs) such as phosphorylation, ubiquitination or
glycosylation are processes affecting the conformation, stability, localization and function of …

Objective We explored the hypothesis that TGR5, the bile acid (BA) G-protein-coupled
receptor highly expressed in biliary epithelial cells, protects the liver against BA overload …

Phosphorylation is a dynamic post-translational modification that can alter protein structure,
localization, protein-protein interactions and stability. All of the identified tight junction …

The term blood–bile barrier (BBlB) refers to the physical structure within a hepatic lobule that
compartmentalizes and hence segregates sinusoidal blood from canalicular bile. Thus, this …

Hepatocytes, the main epithelial cell type of the liver, function like all epithelial cells to
mediate the vectorial flow of macromolecules into and out of the organ they encompass …