An overview on synthetic and pharmaceutical prospective of pyrido[2,3‐d]pyrimidines scaffold
Abstract Pyrido [2, 3‐d] pyrimidine, a fused hetero‐bicyclic nucleus containing pyridine and
pyrimidine rings has attained the momentary attention in the sphere of multicomponent …
pyrimidine rings has attained the momentary attention in the sphere of multicomponent …
4-(5-Amino-pyrazol-1-yl) benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and …
In the current medical era, the single target inhibition paradigm of drug discovery has given
way to the multi-target design concept. As the most intricate pathological process …
way to the multi-target design concept. As the most intricate pathological process …
3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and …
Herein we describe the design and synthesis of two series of sulfonamides featuring N-
unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to …
unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to …
Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies
A Sabt, OM Abdelhafez, RS El-Haggar… - Journal of enzyme …, 2018 - Taylor & Francis
Herein, we report the synthesis of different novel sets of coumarin-6-sulfonamide derivatives
bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro …
bearing different functionalities (4a, b, 8a–d, 11a–d, 13a, b, and 15a–c), and in vitro …
Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted …
Herein we report the design and synthesis of novel N-substituted isatins-SLC-0111 hybrids
(6a-f and 9a-l). A structural extension approach was adopted via N-alkylation and N …
(6a-f and 9a-l). A structural extension approach was adopted via N-alkylation and N …
Novel 3-substituted coumarins as selective human carbonic anhydrase IX and XII inhibitors: Synthesis, biological and molecular dynamics analysis
In this study, diverse series of coumarin derivatives were developed as potential carbonic
anhydrase inhibitors (CAIs). A “tail” approach was adopted by selecting the coumarin motif …
anhydrase inhibitors (CAIs). A “tail” approach was adopted by selecting the coumarin motif …
Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors
In the present study, we describe the design of different series of benzofuran-based
derivatives as potential carbonic anhydrase inhibitors (CAIs). The adopted design is based …
derivatives as potential carbonic anhydrase inhibitors (CAIs). The adopted design is based …
Tumor-associated carbonic anhydrase isoform IX and XII inhibitory properties of certain isatin-bearing sulfonamides endowed with in vitro antitumor activity towards …
Three series of indolinone-based sulfonamides (3a–f, 6a–f and 9a–f) were in vitro evaluated
as inhibitors of the tumor-associated carbonic anhydrase (CA, EC 4.2. 1.1) isoforms hCA IX …
as inhibitors of the tumor-associated carbonic anhydrase (CA, EC 4.2. 1.1) isoforms hCA IX …
Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX
Limited presence of hCA IX in normal physiological tissues and their overexpression only in
solid hypoxic tumors made this isoform excellent possible target for developing new …
solid hypoxic tumors made this isoform excellent possible target for developing new …
Synthesis, biological and molecular dynamics investigations with a series of triazolopyrimidine/triazole-based benzenesulfonamides as novel carbonic anhydrase …
In the presented work, we report the design and synthesis of different new sets of
triazolopyrimidine-based (9a-d) and triazole-based (11a-h, 13a-c, 15a, b, 17a, b and 21a-g) …
triazolopyrimidine-based (9a-d) and triazole-based (11a-h, 13a-c, 15a, b, 17a, b and 21a-g) …