Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

The design of the energy metabolism system in striated muscle remains a major area of
investigation. Here, we review our current understanding and emerging hypotheses …

Optical mapping is a high-resolution fluorescence imaging technique, that uses voltage-or
calcium-sensitive dyes to visualize electrical excitation waves on the heart surface …

Optical mapping is an imaging technique that is extensively used in cardiovascular
research, wherein parameter-sensitive fluorescent indicators are used to study the …

Genetic engineering and implantable bioelectronics have transformed investigations of
cardiovascular physiology and disease. However, the two approaches have been difficult to …

Rationale: Sarcoplasmic reticulum (SR) Ca2+ cycling is key to normal excitation–contraction
coupling but may also contribute to pathological cardiac alternans and arrhythmia …

Optical mapping of Ca2+-sensitive fluorescence probes has become an extremely useful
approach and adopted by many cardiovascular research laboratories to study a spectrum of …

Systemic iron deficiency (SID), even in the absence of anaemia, worsens the prognosis and
increases mortality in heart failure (HF). Recent clinical–epidemiological studies, however …

Recent developments in optophysiology techniques such as optogenetics have
revolutionized the ability to actuate cell activity. Further combining optophysiology and …

Cardiac optical mapping, also known as optocardiography, employs parameter-sensitive
fluorescence dye (s) to image cardiac tissue and resolve the electrical and calcium …