Dopamine (DA) regulates emotional and motivational behavior through the mesolimbic
dopaminergic pathway. Changes in DA mesolimbic neurotransmission have been found to …

The question of addiction concerns the process by which drug‐taking behavior, in certain
individuals, evolves into compulsive patterns of drug‐seeking and drug‐taking behavior that …

Rational and objectives. The reinstatement model is currently used in many laboratories to
investigate mechanisms underlying relapse to drug seeking. Here, we review briefly the …

The question of addiction specifically concerns (1), the process by which drug‐taking
behavior, in certain individuals, evolves into compulsive patterns of drug‐seeking and drug …

Rationale and objectives: Repeated exposure to many drugs of abuse results in a
progressive and enduring enhancement in the motor stimulant effect elicited by a …

The role of limbic-striato-pallidal circuitry in cocaine-induced reinstatement was evaluated.
The transient inhibition of brain nuclei associated with motor systems [including the ventral …

The relative contributions of glutamate and dopamine within the nucleus accumbens to
cocaine-induced reinstatement of drug-seeking behavior were assessed. When …

Amphetamine microinjection into the nucleus accumbens shell enhanced the ability of a
Pavlovian reward cue to trigger increased instrumental performance for sucrose reward in a …

The objective of this article is to review data from studies that used a reinstatement model in
rats to elucidate the neural mechanisms underlying relapse to heroin and cocaine seeking …

It is commonly held that substance use comorbidity in schizophrenia represents self-
medication, an attempt by patients to alleviate adverse positive and negative symptoms …