Withaferin A (WA) is a natural steroidal compound used in Ayurvedic medicine in India and
elsewhere. Although WA was used as an anticancer reagent for decades, its role in the …

Abstract Amomum Tsaoko Crevost et Lemarie is a kind of spices and traditional Chinese
medicines with great commercial value. Traditional treatment often uses essential oils from …

Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa. M2 macrophage
polarization can reduce inflammation and repair tissue injury during AR development …

Purpose Drug-resistant gram-negative bacteria have emerged as a global crisis. Therefore,
novel antibiotics and novel anti-infection strategies are urgently needed. Current antibiotics …

There are multiple lines of evidence for the existence of communication between the central
nervous system (CNS), gut, and intestinal microbiome. Despite extensive analysis …

Small modifications in the chemical structure of ligands are known to dramatically change
their ability to inhibit the activity of a protein. Unraveling the mechanisms that govern these …

Cytokines and chemokines are secreted proteins that regulate various biological processes,
such as inflammation, immune response, and cell differentiation. Therefore, disruption of …

Abstract Glycogen synthase kinase-3 (GSK-3) has been implicated in numerous pathologies
making GSK-3 an attractive therapeutic target. Our group has identified a compound termed …

Tumor-associated macrophages (TAMs) exert profound influence over breast cancer
progression, promoting immunosuppression, angiogenesis, and metastasis. Neuropilin-2 …

During a SARS-CoV-2 infection, macrophages recognize viral components resulting in
cytokine production. While this response fuels virus elimination, overexpression of cytokines …