A role for neutrophils in viral respiratory disease

JV Camp, CB Jonsson - Frontiers in immunology, 2017 - frontiersin.org
Neutrophils are immune cells that are well known to be present during many types of lung
diseases associated with acute respiratory distress syndrome (ARDS) and may contribute to …

Respiratory viral infections and host responses; insights from genomics

NM Troy, A Bosco - Respiratory research, 2016 - Springer
Respiratory viral infections are a leading cause of disease and mortality. The severity of
these illnesses can vary markedly from mild or asymptomatic upper airway infections to …

Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic

LV Patrono, B Vrancken, M Budt, A Düx… - Nature …, 2022 - nature.com
The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century
and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here …

[HTML][HTML] Diversity in heat shock protein families: functional implications in virus infection with a comprehensive insight of their role in the HIV-1 life cycle

K Iyer, K Chand, A Mitra, J Trivedi, D Mitra - Cell Stress and Chaperones, 2021 - Elsevier
Heat shock proteins (HSPs) are a group of cellular proteins that are induced during stress
conditions such as heat stress, cold shock, UV irradiation and even pathogenic insult. They …

Hemagglutinin cleavability, acid stability, and temperature dependence optimize influenza B virus for replication in human airways

M Laporte, A Stevaert, V Raeymaekers… - Journal of …, 2019 - Am Soc Microbiol
Influenza A virus (IAV) and influenza B virus (IBV) cause yearly epidemics with significant
morbidity and mortality. When zoonotic IAVs enter the human population, the viral …

“国际公共卫生紧急事件” 下的mRNA 疫苗研发

叶青, 秦成峰 - 合成生物学, 2024 - synbioj.cip.com.cn
“国际公共卫生紧急事件”(简称PHEIC) 是指疾病的国际传播对其他国家构成公共卫生风险,
需要采取协调一致的国际应对措施的不同寻常事件. 迄今为止, 世界卫生组织(WHO) …

Human properdin released by infiltrating neutrophils can modulate Influenza A virus infection

PM Varghese, S Mukherjee, FA Al-Mohanna… - Frontiers in …, 2021 - frontiersin.org
The complement system is designed to recognise and eliminate invading pathogens via
activation of classical, alternative and lectin pathways. Human properdin stabilises the …

Innate immune responses at the asymptomatic stage of influenza A viral infections of Streptococcus pneumoniae colonized and non-colonized mice

F Cuypers, A Schäfer, SB Skorka, S Surabhi… - Scientific reports, 2021 - nature.com
Abstract Seasonal Influenza A virus (IAV) infections can promote dissemination of upper
respiratory tract commensals such as Streptococcus pneumoniae to the lower respiratory …

[HTML][HTML] PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice

K Cheng, Z Yu, H Chai, W Sun, Y Xin, Q Zhang… - Virology, 2014 - Elsevier
H6N1 avian influenza viruses (AIVs) may pose a potential human risk as suggested by the
first documented naturally-acquired human H6N1 virus infection in 2013. Here, we set out to …

Molecular determinants of influenza virus pathogenesis in mice

RP Kamal, JM Katz, IA York - Influenza Pathogenesis and Control-Volume …, 2014 - Springer
Mice are widely used for studying influenza virus pathogenesis and immunology because of
their low cost, the wide availability of mouse-specific reagents, and the large number of …