The oxidative stress and chronic inflammatory process in Chagas disease: role of exosomes and contributing genetic factors

E Maldonado, DA Rojas, F Urbina… - Oxidative Medicine and …, 2021 - Wiley Online Library
Chagas disease is a neglected tropical disease caused by the flagellated protozoa
Trypanosoma cruzi that affects several million people mainly in Latin American countries …

Aspirin and infection: A narrative review

S Di Bella, R Luzzati, L Principe, V Zerbato, E Meroni… - Biomedicines, 2022 - mdpi.com
Acetylsalicylic acid (ASA) is one of the most commonly used drugs in the world. It derives
from the extract of white willow bark, whose therapeutic potential was known in Egypt since …

Aspirin-triggered resolvin D1 reduces parasitic cardiac load by decreasing inflammation in a murine model of early chronic Chagas disease

I Carrillo, RAN Rabelo, C Barbosa… - PLoS Neglected …, 2021 - journals.plos.org
Background Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in
Latin America and is widely distributed worldwide because of migration. In 30% of cases …

Immunomodulation for the treatment of chronic chagas disease cardiomyopathy: A new approach to an old enemy

ES Santos, DKC Silva, BPZC Reis… - Frontiers in Cellular …, 2021 - frontiersin.org
Chagas disease is a parasitic infection caused by the intracellular protozoan Trypanosoma
cruzi. Chronic Chagas cardiomyopathy (CCC) is the most severe manifestation of the …

Natural sesquiterpene lactones induce programmed cell death in Trypanosoma cruzi: a new therapeutic target?

V Jimenez, U Kemmerling, R Paredes, JD Maya… - Phytomedicine, 2014 - Elsevier
Abstract Background Chagas disease or American Trypanosomiasis is caused by the
flagellated protozoan parasite Trypanosoma cruzi (T. cruzi) and is recognized by the WHO …

The effect of acetyl salicylic acid (Aspirin) on trophoblast-endothelial interaction in vitro

B Xu, R Shanmugalingam, K Chau, S Pears… - Journal of Reproductive …, 2017 - Elsevier
Early administration of low dose acetyl salicylic acid (Aspirin) in high risk women reduces
the risk of early onset preeclampsia. This study aims to investigate the effect of aspirin on …

Simvastatin attenuates endothelial activation through 15-epi-lipoxin A4 production in murine chronic Chagas cardiomyopathy

F González-Herrera, A Cramer, P Pimentel… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Current treatments for chronic Chagas cardiomyopathy, a disease with high mortality rates
and caused by the protozoan Trypanosoma cruzi, are unsatisfactory. Myocardial …

Inflammatory and pro-resolving lipids in trypanosomatid infections: a key to understanding parasite control

RA López-Muñoz, A Molina-Berríos… - Frontiers in …, 2018 - frontiersin.org
Pathogenic trypanosomatids (Trypanosoma cruzi, Trypanosoma brucei, and Leishmania
spp.) are protozoan parasites that cause neglected diseases affecting millions of people in …

Aspirin plus verapamil relieves angina and perfusion abnormalities in patients with coronary microvascular dysfunction and Chagas disease: a pilot non-randomized …

RB Pavão, HT Moreira, AO Pintya… - Revista da Sociedade …, 2021 - SciELO Brasil
INTRODUCTION: Most patients with chronic cardiomyopathy of Chagas disease (CCCD)
harbor a secondary cause of coronary microvascular dysfunction (CMD), for which there is …

[HTML][HTML] The role of vascular endothelium and exosomes in human protozoan parasitic diseases

S Varikuti, BK Jha, EA Holcomb, JC McDaniel… - Vessel plus, 2020 - ncbi.nlm.nih.gov
The vascular endothelium is a vital component in maintaining the structure and function of
blood vessels. The endothelial cells (ECs) mediate vital regulatory functions such as the …