Seeking heterocyclic scaffolds as antivirals against dengue virus
Dengue is one of the most typical viral infection categorized in the Neglected Tropical
Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and …
Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and …
Exploration of novel VEGFR2 tyrosine kinase inhibitors via design and synthesis of new alkylated indolyl-triazole Schiff bases for targeting breast cancer
MS Nafie, ATA Boraei - Bioorganic Chemistry, 2022 - Elsevier
Abstract According to the World Health Organization (WHO) statistics: In 2020, there were
2.3 million women diagnosed with breast cancer and 685,000 deaths globally. Therefore …
2.3 million women diagnosed with breast cancer and 685,000 deaths globally. Therefore …
Discovery of novel pyrazolo [3, 4-b] pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells
MS Nafie, AM Amer, AK Mohamed… - Bioorganic & Medicinal …, 2020 - Elsevier
Pim-1 kinase targeted recently has proved an essential goal of breast cancer therapy. We
report the design, synthesis with full characterization analysis of pyrazolo [3, 4-b] pyridine …
report the design, synthesis with full characterization analysis of pyrazolo [3, 4-b] pyridine …
Nitrogen‐Containing Heterocyclic Scaffolds as EGFR Inhibitors: Design Approaches, Molecular Docking, and Structure‐Activity Relationships
Cancer is a wide collection of diseases and among the numerous pathways involved in
cancer pathogenesis, pathway involving epidermal growth factor receptor (EGFR) is one of …
cancer pathogenesis, pathway involving epidermal growth factor receptor (EGFR) is one of …
Synthesis of new substituted pyridine derivatives as potent anti-liver cancer agents through apoptosis induction: In vitro, in vivo, and in silico integrated approaches
ATA Boraei, EH Eltamany, IAI Ali, SM Gebriel… - Bioorganic …, 2021 - Elsevier
Liver cancer is the most common type of cancer in many countries. New studies and
statistics show rising liver cancer worldwide, so it is essential to seek new agents for this …
statistics show rising liver cancer worldwide, so it is essential to seek new agents for this …
Discovery of PIM-1 kinase inhibitors based on the 2, 5-disubstituted 1, 3, 4-oxadiazole scaffold against prostate cancer: Design, synthesis, in vitro and in vivo …
PIM-1 kinases play an established role in prostate cancer development and progression.
This research work tackles the design and synthesis of new PIM-1 kinase targeting 2, 5 …
This research work tackles the design and synthesis of new PIM-1 kinase targeting 2, 5 …
[HTML][HTML] Comparative Assessment of the Antioxidant and Anticancer Activities of Plicosepalus acacia and Plicosepalus curviflorus: Metabolomic Profiling and In Silico …
This study presents a comparison between two mistletoe plants—P. acacia and P.
curviflorus—regarding their total phenolic contents and antioxidant and anticancer activities …
curviflorus—regarding their total phenolic contents and antioxidant and anticancer activities …
[HTML][HTML] Chemical constituents from Carica papaya Linn. leaves as potential cytotoxic, EGFR wt and aromatase (CYP19A) inhibitors; a study supported by molecular …
The phytochemical investigation of the hydromethanolic extract of Carica papaya Linn.
leaves (Caricaceae) resulted in the isolation and characterization of ten compounds …
leaves (Caricaceae) resulted in the isolation and characterization of ten compounds …
[HTML][HTML] Synthesis of novel mono-and bis-pyrazolylthiazole derivatives as anti-liver cancer agents through EGFR/HER2 target inhibition
Bromoacetyl-4-(2-naphthoyl)-1-phenyl-1H-pyrazole (6) was synthesized from 2-
acetylnaphthalene and was used as a new key building block for constructing the title …
acetylnaphthalene and was used as a new key building block for constructing the title …
[HTML][HTML] Chemical Profiling, Antioxidant, Cytotoxic Activities and Molecular Docking Simulation of Carrichtera annua DC. (Cruciferae)
Our investigation intended to analyze the chemical composition and the antioxidant activity
of Carrichtera annua and to evaluate the antiproliferative effect of C. annua crude and …
of Carrichtera annua and to evaluate the antiproliferative effect of C. annua crude and …