The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …

Melanoma is one of the most lethal neoplasms of the skin. Despite the revolutionary
introduction of immune checkpoint inhibitors, metastatic spread, and recurrence remain …

Melanoma is among the most lethal forms of cancer, accounting for 80% of deaths despite
comprising just 5% of skin cancer cases. Treatment options remain limited due to the genetic …

Simple Summary Resistance to standard therapies represents a major challenge in
melanoma treatment. This is mainly related to the high heterogeneity of this malignancy due …

Despite significant advances in targeted therapies against the hyperactivated
BRAFV600/MEK pathway for patients with unresectable metastatic melanoma, acquired …

The composition and cellular heterogeneity of the corpus cavernosum (CC)
microenvironment have been characterized, but the spatial heterogeneity at the molecular …

Tumor cells can undergo metabolic adaptations that support their growth, invasion, and
metastasis, such as reprogramming lipid metabolism to meet their energy demands and to …

Aim: This study aimed to explore using peripheral blood mononuclear cell (PBMC)-derived
chimeric antigen receptor (CAR) NK cells targeting ROBO1 as a personalized medicine …

Repurposing existing drugs for cancer therapy has become an important strategy because
of its advantages, such as cost reduction, effect and safety. The present study was designed …

Tumor cells can undergo metabolic adaptations that support their growth, invasion, and
metastasis, such as reprogramming lipid metabolism to meet their energy demands and to …