Within weeks of the first report of acquired immunodeficiency syndrome (AIDS) in 1981, it
was observed that these patients often had Kaposi sarcoma (KS), a hitherto rarely seen skin …

The immune system of people living with HIV (PLWH) is persistently exposed to antigens
leading to systemic inflammation despite combination antiretroviral treatment (cART). This …

This manuscript describes the Advanced Breast Cancer (ABC) international consensus
guidelines updated at the last two ABC international consensus conferences (ABC 6 in …

Liver cancer is a major global health concern, ranking among the top causes of cancer-
related deaths worldwide. Despite advances in medical research, the prognosis for liver …

The Oncology Grand Rounds series is designed to place original reports published in the
Journal into clinical context. A case presentation is followed by a description of diagnostic …

PURPOSE Cancer Immunotherapy Trials Network 12 demonstrated safety of
pembrolizumab in treating advanced cancer in people with HIV. Here, we report results of …

Over the last decade, immune checkpoint inhibitors (ICIs) have been established as an
integral component of the contemporary anticancer armamentarium. In dermatology, ICIs are …

Immune checkpoints are differentially expressed on various immune cells to regulate
immune responses in tumor microenvironment. Tumor cells can activate the immune …

Simple Summary Metastatic melanoma treatment has greatly changed in the last decade
due to the introduction of target therapies and immune checkpoint inhibitors. The …

Immunotherapy has revolutionized cancer therapy and now represents a standard of care
for many tumor types, including triple-negative breast cancer. Despite the positive results …