For a blood-borne cancer therapeutic agent to be effective, it must cross the blood vessel
wall to reach cancer cells in adequate quantities, and it must overcome the resistance …

Mitochondrial dysfunction and excessive inflammatory responses are both sufficient to
induce pathology in age-dependent neurodegenerations. However, emerging evidence …

Adeno-associated viral vectors (AAVs) have become popular for gene therapy, given their
many advantages, including their reduced inflammatory profile compared with that of other …

Glioma is a mixed solid tumor composed of neoplastic and non-neoplastic components.
Glioma-associated macrophages and microglia (GAMs) are crucial elements of the glioma …

Microglial cells are crucial in maintaining central nervous system (CNS) homeostasis and
mediating CNS disease pathogenesis. Increasing evidence supports that alterations in the …

Neuroinflammation is considered one of the cardinal features of Alzheimer's disease (AD).
Neuritic plaques composed of amyloid β and neurofibrillary tangle-laden neurons are …

Background Cardiovascular diseases, including heart failure, are the most common cause of
death globally. Recent studies support a high degree of comorbidity between heart failure …

Cerebral vascular injury as a consequence of blast-induced traumatic brain injury is
primarily the result of blast wave-induced mechanical disruptions within the neurovascular …

Abstract Purpose of Review Postoperative cognitive dysfunction (POCD) occurs in 20–50%
of postsurgical patients with a higher prevalence in elderly patients and patients with …

More than 500 million people worldwide are infected each year by any of the four-dengue
virus (DENV) serotypes. The clinical spectrum caused during these infections is wide and …