Unique, functional, homodimeric heavy chain–only antibodies, devoid of light chains, are
circulating in the blood of Camelidae. These antibodies recognize their cognate antigen via …

Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

The interface of bio–nano science and cancer medicine is an area experiencing much
progress but also beset with controversy. Core concepts of the field eg, the enhanced …

Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …

Sera of camelids contain both conventional heterotetrameric antibodies and unique
functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric …

Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with
many unique properties such as small size, excellent solubility, superior stability, quick …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

Ultrasmall nanoparticulate materials with core sizes in the 1-3 nm range bridge the gap
between single molecules and classical, larger-sized nanomaterials, not only in terms of …

Tremendous effort has been expended over the past two and a half decades to understand
many aspects of camelid heavy chain antibodies, from their biology, evolution, and …

Human epidermal growth factor receptor 2 (HER2) status is one of the major tumor
characteristics in breast cancer to guide therapy. Anti-HER2 treatment has clear survival …