Acute hypoxic–ischemic encephalopathy around the time of birth remains a major cause of
death and life-long disability. The key insight that led to the modern revival of studies of …

Neonatal encephalopathy is a clinical syndrome of neurologic dysfunction that
encompasses a broad spectrum of symptoms and severity, from mild irritability and feeding …

Seizures are the most common neurological emergency in the neonatal period and in
contrast to those in infancy and childhood, are often provoked seizures with an acute cause …

METHODS: The study was a multicenter, randomized, blinded, controlled, phase IIb trial
investigating the efficacy and safety of levetiracetam compared with phenobarbital as a first …

Background Despite the availability of continuous conventional electroencephalography
(cEEG), accurate diagnosis of neonatal seizures is challenging in clinical practice …

Importance Antiseizure medication (ASM) treatment duration for acute symptomatic neonatal
seizures is variable. A randomized clinical trial of phenobarbital compared with placebo after …

Objective: Although individual neonatal epilepsy syndromes are rare, as a group they
represent a sizable subgroup of neonatal seizure etiologies. We evaluated the profile of …

Objective To assess the impact of the time to treatment of the first electrographic seizure on
subsequent seizure burden and describe overall seizure management in a large neonatal …

Objective In the absence of controlled trials, treatment of neonatal seizures has changed
minimally despite poor drug efficacy. We tested bumetanide added to phenobarbital to treat …

Objective Although most seizures in neonates are due to acute brain injury, some represent
the first sign of neonatal onset genetic epilepsies. Delay in recognition and lack of expert …