Protein glycosylation involves the co-translational or post-translational addition of glycans to
proteins and is a crucial protein modification in health and disease. The aim of …

Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient
survival. Toward understanding the underlying molecular alterations that drive PDAC …

Glycosylation is a prevalent, yet heterogeneous modification with a broad range of
implications in molecular biology. This heterogeneity precludes enrichment strategies that …

Inter-tumor heterogeneity is a result of genomic, transcriptional, translational, and post-
translational molecular features. To investigate the roles of protein glycosylation in the …

Artificial intelligence (AI) methods have been and are now being increasingly integrated in
prediction software implemented in bioinformatics and its glycoscience branch known as …

Metabolic labeling of glycans with clickable unnatural sugars has enabled glycan analysis in
multicellular systems. However, cell-type-specific labeling of glycans in vivo remains …

ADP-ribosylation (ADPr) is a post-translational modification that plays pivotal roles in a wide
range of cellular processes. Mass spectrometry (MS)-based analysis of ADPr under …

O-linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification (ie, O-
GlcNAcylation) on the serine/threonine residues of proteins. As a unique intracellular …

Post-translational modifications (PTMs) are critical molecular mechanisms that regulate
protein functions temporally and spatially in various organisms. Since most PTMs are …