Extensive migration has led to the necessity of knowledge regarding the treatment of
migrants with different ethnical backgrounds. This is especially relevant for pharmacological …

Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …

The present study evaluates the worldwide frequency distribution of CYP2C19 alleles and
CYP2C19 metabolic phenotypes ('predicted'from genotypes and 'measured'with a probe …

Background: Individual response to opioid analgesics varies among patients. Objective: This
study sought to clarify the impact of distinct genetic variations on pain, opioid consumption …

Understanding the prevalence of clinically relevant pharmacogenetic variants using large
unselected populations is critical for gauging the potential clinical impact of widespread …

The main objective of this study is to assess the effects of CYP2C9 and VKORC1
polymorphisms on warfarin sensitivity and responsiveness in a Jordanian population during …

Esophageal cancer (EC) is one of the most common malignancies in low-and medium-
income countries and represents a disease of public health importance because of its poor …

Background Compared with western countries, Asian breast cancer patients have unique
pathological and biological characteristics. Most of them are premenopausal women with …

Abstract CYP2C9 metabolizes approximately 20% of clinically used drugs, including the
narrow therapeutic window drugs warfarin and phenytoin. More than 16,000 variants have …

Purpose Several severe drug interactions have been reported when sildenafil, a potent drug
for the treatment of erectile dysfunction, is co-administered with drugs or herbal remedies …