Neutrophils or polymorphonuclear leukocytes (PMN) are key participants in the innate
immune response for their ability to execute different effector functions. These cells express …

Neutrophils play a central role in innate immunity, inflammation, and resolution. Unresolving
neutrophilia features as a disrupted inflammatory process in the airways of patients with …

The circadian system is an important regulator of immune function. Human inflammatory
lung diseases frequently show time-of-day variation in symptom severity and lung function …

Oxidative stress is caused predominantly by accumulation of hydrogen peroxide and
distinguishes inflamed tissue from healthy tissue. Hydrogen peroxide could potentially be …

Chronic obstructive pulmonary disease (COPD) is a progressive condition of chronic
bronchitis, small airway obstruction, and emphysema that represents a leading cause of …

The successful resolution of inflammation is dependent upon the coordinated transition from
the initial recruitment of neutrophils to a more sustained population of mononuclear cells. IL …

Chronic obstructive pulmonary disease (COPD) is a debilitating respiratory disease and one
of the leading causes of morbidity and mortality worldwide. It is characterized by persistent …

Chronic respiratory diseases (CRDs) are an important factor of morbidity and mortality,
accounting for approximately 6% of total deaths worldwide. The main CRDs are asthma and …

Many lung diseases are characterized by neutrophil-dominated inflammation; therefore, an
understanding of neutrophil function is of considerable importance to respiratory physicians …

Abstract Background Asthma-COPD overlap (ACO) refers to a group of poorly studied and
characterised patients reporting with disease presentations of both asthma and COPD …