The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …

Ischemia—Reperfusion injury of the intestine is a significant problem in abdominal aortic
aneurysm surgery, small bowel transplantation, cardiopulmonary bypass, strangulated …

The damaging effects of intestinal ischemia-reperfusion (I/R) on the gut and remote organs
can be attenuated by subjecting the intestine to a prior, less severe I/R insult, a process …

Background: Intestinal ischemia/reperfusion (I/R) injury is a clinical challenge with high
morbidity and mortality, whereas the effective therapeutic strategy is limited. Inflammatory …

Results: Histological results showed severe damage in the intestinal mucosa of the injury
group accompanied by increases in MDA, NO and ET-1 and a decrease in SOD activity …

Background Ischemic preconditioning (IP) has emerged as a powerful experimental method
of ameliorating ischemic injury in a variety of organs. This systematic review examines the …

Background Ischaemia–reperfusion (IR) injury of the intestine occurs commonly during
abdominal surgery. Ischaemic preconditioning (IPC) provides a way of protecting the organ …

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with potent
neurotrophic and neuroprotective effects. We have previously shown that PACAP protects …

Pituitary adenylate cyclase-activating polypeptide (PACAP) is present in the gastrointestinal
tract and plays a central role in the intestinal physiology, mainly in the secretion and motility …

Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous neuropeptide
widely distributed throughout the body, including the gastrointestinal tract. Several effects …