Review of the synthesis and biological activity of thiazoles

SH Ali, AR Sayed - Synthetic Communications, 2021 - Taylor & Francis
This study covers the literature documents available on the chemistry of preparation of
thiazoles. Additionally, we cover the biological activities of certain thiazoles. The information …

Thiazole compounds as antiviral agents: An update

IP Singh, S Gupta, S Kumar - Medicinal Chemistry, 2020 - ingentaconnect.com
Background: Thiazole is a good nucleus owing to its various pharmaceutical applications.
Thiazole containing compounds (thiazoles) have shown various biological activities like …

Comparison of the interactions of fanetizole with pepsin and trypsin: Spectroscopic and molecular docking approach

Y Yue, Q Tu, Y Guo, Y Wang, Y Xu, Y Zhang… - Journal of Molecular …, 2022 - Elsevier
In this work, the binding affinity of fanetizole with proteases pepsin and trypsin were
investigated by spectroscopy and molecular docking. As a thiazole derivative, the …

Design, synthesis and biological evaluation of new series of benzotriazole-pyrazole clubbed thiazole hybrids as bioactive heterocycles: Antibacterial, antifungal …

KB Gangurde, RA More, VA Adole… - Journal of Molecular …, 2024 - Elsevier
The need for novel heterocyclic compounds with robust biological action is a result of the
emergence of numerous pandemics and microbial resistance. To search antibacterial and …

Thiazole and related heterocyclic systems as anticancer agents: A review on synthetic strategies, mechanisms of action and SAR Studies

Sahil, K Kaur, V Jaitak - Current medicinal chemistry, 2022 - benthamdirect.com
Background: Cancer is the second leading cause of death worldwide. Many anticancer
drugs are commercially available, but lack of selectivity, target specificity, cytotoxicity, and …

New thiourea and benzamide derivatives of 2-aminothiazole as multi-target agents against Alzheimer's disease: Design, synthesis, and biological evaluation

B Kilic, M Bardakkaya, RI Sagkan, F Aksakal… - Bioorganic …, 2023 - Elsevier
In this study, two series of compounds were designed and synthesized, bearing thiourea
and benzamide derivatives at position 2 of 4-subtituted-2-aminothiazole, respectively. Then …

Synthesis and molecular docking of novel 1, 3-thiazole derived 1, 2, 3-triazoles and in vivo biological evaluation for their anti anxiety and anti inflammatory activity

KN Ankali, J Rangaswamy, M Shalavadi, N Naik… - Journal of Molecular …, 2021 - Elsevier
Heterocyclic rings such as thiazole and triazole are considered as privileged moieties, since
they constitute several drugs for biological treatment. In this work, a novel series of 1, 3 …

Discovery of novel JAK2 and EGFR inhibitors from a series of thiazole-based chalcone derivatives

K Sanachai, T Aiebchun, P Mahalapbutr… - RSC Medicinal …, 2021 - pubs.rsc.org
The Janus kinase (JAK) and epidermal growth factor receptor (EGFR) have been
considered as potential targets for cancer therapy due to their role in regulating proliferation …

I 2/TBHP-Mediated tandem cyclization and oxidation reaction: Facile access to 2-substituted thiazoles and benzothiazoles

L Liu, C Tan, R Fan, Z Wang, H Du, K Xu… - Organic & Biomolecular …, 2019 - pubs.rsc.org
The efficient synthesis of 2-substituted thiazoles and benzothiazoles has been
accomplished employing readily available cysteine esters and 2-aminobenzenethiols as N …

Palladium-metalated porous organic polymers as recyclable catalysts for the chemioselective synthesis of thiazoles from thiobenzamides and isonitriles

W Tong, WH Li, Y He, ZY Mo, HT Tang, HS Wang… - Organic …, 2018 - ACS Publications
Two types of thiazole derivatives are synthesized through a multistep cascade sequence
with Pd-metalated phosphorus-doped porous organic polymers (POPs) as heterogeneous …