Abstract In 1994, the “danger model” argued that adaptive immune responses are driven
rather by molecules released upon tissue damage than by the recognition of “strange” …

Sepsis remains a leading cause of death worldwide, despite advances in critical care, and
understanding of the pathophysiology and treatment strategies. No specific therapy or drugs …

Traumatic brain injury (TBI) is a serious global health issue, being the leading cause of
death and disability for individuals under the age of 45, and one of the largest causes of …

Septic acute kidney injury (AKI) and myocardial dysfunction are leading causes of mortality
with no accepted method of therapy. In this study we demonstrate the role of growth …

In sepsis‐3, in contrast with sepsis‐1, the definition “systemic inflammatory response” has
been replaced with “dysregulated host response”, and “systemic inflammatory response …

This review summarizes a short list of currently discussed trauma-induced danger-
associated molecular patterns (DAMP). Due to the bivalent character and often pleiotropic …

Sepsis is a life-threatening disorder that is caused by a dysregulated inflammatory response
during an infection. The disease mostly affects pregnant women, newborns, and patients in …

Inflammation is a tightly coordinated response of the host immune system to bacterial and
viral infections, triggered by the production of inflammatory cytokines. Sepsis is defined as a …

Introduction. When sepsis attacks the body, the excessive reactive oxygen species (ROS)
production can result to endoplasmic reticulum stress (ERS) and eventually cause …

Introduction Sepsis is a severe reaction and excessive immune response to infection, which
can lead to tissue damage, organ dysfunction, and death. This study aimed to investigate the …