The epigenetic modifications of histones are versatile marks that are intimately connected to
development and disease pathogenesis including human cancers. In this review, we will …

The DNA of each cell is wrapped around histone octamers, forming so-called 'nucleosomal
core particles'. These histone proteins have tails that project from the nucleosome and many …

Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …

A major mechanism regulating the accessibility and function of eukaryotic genomes are the
covalent modifications to DNA and histone proteins that dependably package our genetic …

Intrinsically disordered proteins (IDPs) lack stable tertiary and/or secondary structures under
physiological conditions in vitro. They are highly abundant in nature and their functional …

Methylation of position-specific lysine residues in histone N termini is a central modification
for regulating epigenetic transitions in chromatin. Each methylatable lysine residue can exist …

Chromatin is the physiologically relevant substrate for all genetic processes inside the nuclei
of eukaryotic cells. Dynamic changes in the local and global organization of chromatin are …

Electron micrographs first confirmed that the eukaryotic genome is organized into repeating
disk-shaped nucleosomal units composed of histones and their associated DNA. Those …

Nucleosomes are the smallest structural unit of chromatin, composed of 147 base pairs of
DNA wrapped around an octamer of histone proteins. Histone function is mediated by …

Post-translational modifications of the histone tails are correlated with distinct chromatin
states that regulate access to DNA. Recent proteomic analyses have revealed several new …