An unprecedented revolution in medicinal chemistry driven by the progress of biological science
KC Chou - Current topics in medicinal chemistry, 2017 - ingentaconnect.com
The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …
various diseases and extend human beings' life as long as possible. Human being is a …
Quorum sensing across bacterial and viral domains
OP Duddy, BL Bassler - PLoS pathogens, 2021 - journals.plos.org
Quorum sensing (QS) is a process of cell-to-cell communication that bacteria use to
orchestrate collective behaviors in response to changes in cell population density and …
orchestrate collective behaviors in response to changes in cell population density and …
Origins of coevolution between residues distant in protein 3D structures
I Anishchenko, S Ovchinnikov… - Proceedings of the …, 2017 - National Acad Sciences
Residue pairs that directly coevolve in protein families are generally close in protein 3D
structures. Here we study the exceptions to this general trend—directly coevolving residue …
structures. Here we study the exceptions to this general trend—directly coevolving residue …
iPreny-PseAAC: identify C-terminal cysteine prenylation sites in proteins by incorporating two tiers of sequence couplings into PseAAC
Y Xu, Z Wang, C Li, KC Chou - Medicinal Chemistry, 2017 - ingentaconnect.com
Background: Occurring at the cysteine residue in the C-terminal of a protein, prenylation is a
special kind of post-translational modification (PTM), which may play a key role for statin in …
special kind of post-translational modification (PTM), which may play a key role for statin in …
The Interface of Vibrio cholerae and the Gut Microbiome
The bacterium Vibrio cholerae is the etiologic agent of the severe human diarrheal disease
cholera. The gut microbiome, or the native community of microorganisms found in the …
cholera. The gut microbiome, or the native community of microorganisms found in the …
[HTML][HTML] iNR-2L: A two-level sequence-based predictor developed via Chou's 5-steps rule and general PseAAC for identifying nuclear receptors and their families
Nuclear receptor proteins (NRPs) perform a vital role in regulating gene expression. With the
rapidity growth of NRPs in post-genomic era, it is highly recommendable to identify NRPs …
rapidity growth of NRPs in post-genomic era, it is highly recommendable to identify NRPs …
Repurposing a Two-Component System-Based Biosensor for the Killing of Vibrio cholerae
New strategies to control cholera are urgently needed. This study develops an in vitro proof-
of-concept sense-and-kill system in a wild-type Escherichia coli strain to target the causative …
of-concept sense-and-kill system in a wild-type Escherichia coli strain to target the causative …
Application of machine learning approaches for protein-protein interactions prediction
Background: Proteomics endeavors to study the structures, functions and interactions of
proteins. Information of the protein-protein interactions (PPIs) helps to improve our …
proteins. Information of the protein-protein interactions (PPIs) helps to improve our …
Cross-kingdom inhibition of bacterial virulence and communication by probiotic yeast metabolites
Background Probiotic milk-fermented microorganism mixtures (eg, yogurt, kefir) are
perceived as contributing to human health, and possibly capable of protecting against …
perceived as contributing to human health, and possibly capable of protecting against …
Combined in silico and in vitro study to reveal the structural insights and nucleotide-binding ability of the transcriptional regulator pehr from the phytopathogen …
The transcriptional regulator PehR regulates the synthesis of the extracellular plant cell wall-
degrading enzyme polygalacturonase, which is essential in the bacterial wilt of plants …
degrading enzyme polygalacturonase, which is essential in the bacterial wilt of plants …