Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

S Zeng, X Liu, YS Kafuti, H Kim, J Wang… - Chemical Society …, 2023 - pubs.rsc.org
Since their inception, rhodamine dyes have been extensively applied in biotechnology as
fluorescent markers or for the detection of biomolecules owing to their good optical physical …

Caveat fluorophore: an insiders' guide to small-molecule fluorescent labels

JB Grimm, LD Lavis - Nature Methods, 2022 - nature.com
The last three decades have brought a revolution in fluorescence microscopy. The
development of new microscopes, fluorescent labels and analysis techniques has pushed …

[HTML][HTML] The evolutionary dynamics of extrachromosomal DNA in human cancers

JT Lange, JC Rose, CY Chen, Y Pichugin, L Xie… - Nature …, 2022 - nature.com
Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving
aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of …

[HTML][HTML] Strategies to convert organic fluorophores into red/near-infrared emitting analogues and their utilization in bioimaging probes

M Dai, YJ Yang, S Sarkar, KH Ahn - Chemical Society Reviews, 2023 - pubs.rsc.org
Organic fluorophores aided by current microscopy imaging modalities are essential for
studying biological systems. Recently, red/near-infrared emitting fluorophores have attracted …

Xanthene-Based NIR-II Dyes for In Vivo Dynamic Imaging of Blood Circulation

D Liu, Z He, Y Zhao, Y Yang, W Shi, X Li… - Journal of the American …, 2021 - ACS Publications
Fluorescence bioimaging through the second near-infrared window (NIR-II, 1000–1700 nm)
has attracted much attention due to its deep penetration and high contrast. However …

A general method to improve fluorophores using deuterated auxochromes

JB Grimm, L Xie, JC Casler, R Patel, AN Tkachuk… - Jacs Au, 2021 - ACS Publications
Fluorescence microscopy relies on dyes that absorb and then emit photons. In addition to
fluorescence, fluorophores can undergo photochemical processes that decrease quantum …

Chemical approaches to optimize the properties of organic fluorophores for imaging and sensing

G Jiang, H Liu, H Liu, G Ke, TB Ren… - Angewandte …, 2024 - Wiley Online Library
Organic fluorophores are indispensable tools in cells, tissue and in vivo imaging, and have
enabled much progress in the wide range of biological and biomedical fields. However …

Rational design of polymethine dyes with NIR‐II emission and high photothermal conversion efficiency for multimodal‐imaging‐guided photo‐immunotherapy

XY Ran, P Chen, YZ Liu, L Shi, X Chen… - Advanced …, 2023 - Wiley Online Library
Phototheranostics have emerged and flourished as a promising pattern for cancer
theranostics owing to their precise photoinduced diagnosis and therapeutic to meet the …

ecDNA hubs drive cooperative intermolecular oncogene expression

KL Hung, KE Yost, L Xie, Q Shi, K Helmsauer… - Nature, 2021 - nature.com
Extrachromosomal DNA (ecDNA) is prevalent in human cancers and mediates high
expression of oncogenes through gene amplification and altered gene regulation. Gene …

The HaloTag as a general scaffold for far-red tunable chemigenetic indicators

C Deo, AS Abdelfattah, HK Bhargava, AJ Berro… - Nature chemical …, 2021 - nature.com
Functional imaging using fluorescent indicators has revolutionized biology, but additional
sensor scaffolds are needed to access properties such as bright, far-red emission. Here, we …