Control of selective mRNA translation in neuronal subcellular compartments in health and disease
R Cagnetta, JG Flanagan… - Journal of …, 2023 - Soc Neuroscience
In multiple cell types, mRNAs are transported to subcellular compartments, where local
translation enables rapid, spatially localized, and specific responses to external stimuli …
translation enables rapid, spatially localized, and specific responses to external stimuli …
Structure and function of African swine fever virus proteins: Current understanding
S Yang, C Miao, W Liu, G Zhang, J Shao… - Frontiers in …, 2023 - frontiersin.org
African swine fever virus (ASFV) is a highly infectious and lethal double-stranded DNA virus
that is responsible for African swine fever (ASF). ASFV was first reported in Kenya in 1921 …
that is responsible for African swine fever (ASF). ASFV was first reported in Kenya in 1921 …
Early metformin treatment: An effective approach for targeting fragile X syndrome pathophysiology
JH Choi, L Marsal-García, E Peraldi, C Walters… - Proceedings of the …, 2024 - pnas.org
Fragile X syndrome (FXS) is the most common genetic cause of autism spectrum disorder
engendered by transcriptional silencing of the fragile X messenger ribonucleoprotein 1 …
engendered by transcriptional silencing of the fragile X messenger ribonucleoprotein 1 …
Phytocannabinoids Reduce Inflammation of Primed Macrophages and Enteric Glial Cells: An In Vitro Study
G Cohen, O Gover, B Schwartz - International Journal of Molecular …, 2023 - mdpi.com
Intestinal inflammation is mediated by a subset of cells populating the intestine, such as
enteric glial cells (EGC) and macrophages. Different studies indicate that phytocannabinoids …
enteric glial cells (EGC) and macrophages. Different studies indicate that phytocannabinoids …
Mnk1/2 kinases regulate memory and autism-related behaviours via Syngap1
MAPK interacting protein kinases 1 and 2 (Mnk1/2) regulate a plethora of functions,
presumably via phosphorylation of their best characterized substrate, eukaryotic translation …
presumably via phosphorylation of their best characterized substrate, eukaryotic translation …
African swine fever virus ubiquitin-conjugating enzyme interacts with host translation machinery to regulate the host protein synthesis
L Barrado-Gil, A Del Puerto, R Muñoz-Moreno… - Frontiers in …, 2020 - frontiersin.org
African Swine Fever virus (ASFV) causes one of the most relevant emerging diseases
affecting swine, now extended through three continents. The virus has a large coding …
affecting swine, now extended through three continents. The virus has a large coding …
Unexpected beta-amyloid production by middle doses of resveratrol through stabilization of APP protein and AMPK-mediated inhibition of trypsin-like proteasome …
BG Jang, J Lee, B Choi, YH Koh, MJ Kim - Food and Chemical Toxicology, 2021 - Elsevier
Resveratrol is a drug candidate used for Alzheimer's disease (AD) and shows beneficial
effects in various toxicity and production models, although recent clinical trial data did not …
effects in various toxicity and production models, although recent clinical trial data did not …
Dysregulating mTORC1-4E-BP2 signaling in GABAergic interneurons impairs hippocampus-dependent learning and memory
Memory formation is contingent on molecular and structural changes in neurons in response
to learning stimuli—a process known as neuronal plasticity. The initiation step of mRNA …
to learning stimuli—a process known as neuronal plasticity. The initiation step of mRNA …
[HTML][HTML] The Fundamental Neurobiological Mechanism of Oxidative Stress-Related 4E-BP2 Protein Deamidation
D Joseph - International Journal of Molecular Sciences, 2024 - mdpi.com
Memory impairment is caused by the absence of the 4E-BP2 protein in the brain. This
protein undergoes deamidation spontaneously in the neurons. 4E-BP2 deamidation …
protein undergoes deamidation spontaneously in the neurons. 4E-BP2 deamidation …
TRIP6 regulates the proliferation, migration, invasion and apoptosis of osteosarcoma cells by activating the NF‑κB signaling pathway
W Liu, L Cheng, Q Li, J Jing - Experimental and …, 2020 - spandidos-publications.com
Thyroid hormone receptor‑interacting protein 6 (TRIP6), a member of the zyxin family of Lin‑
Isl‑Mec (LIM) proteins, is an adaptor protein primarily expressed in epithelial cells. TRIP6 …
Isl‑Mec (LIM) proteins, is an adaptor protein primarily expressed in epithelial cells. TRIP6 …