Recent advances in acute kidney injury and its consequences and impact on chronic kidney disease
A Zuk, JV Bonventre - Current opinion in nephrology and …, 2019 - journals.lww.com
Recent advances in acute kidney injury and its consequences... : Current Opinion in
Nephrology and Hypertension Recent advances in acute kidney injury and its …
Nephrology and Hypertension Recent advances in acute kidney injury and its …
[HTML][HTML] Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee …
V Deshmukh, AL O'Green, C Bossard, T Seo… - Osteoarthritis and …, 2019 - Elsevier
Objectives Wnt pathway upregulation contributes to knee osteoarthritis (OA) through
osteoblast differentiation, increased catabolic enzymes, and inflammation. The small …
osteoblast differentiation, increased catabolic enzymes, and inflammation. The small …
Comparative efficacy and selectivity of pharmacological inhibitors of DYRK and CLK protein kinases
MF Lindberg, E Deau, J Arfwedson… - Journal of medicinal …, 2023 - ACS Publications
Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases
(CLKs) play a large variety of cellular functions and are involved in several diseases …
(CLKs) play a large variety of cellular functions and are involved in several diseases …
[HTML][HTML] Targeting CBP and p300: Emerging Anticancer Agents
D Masci, M Puxeddu, R Silvestri, G La Regina - Molecules, 2024 - mdpi.com
CBP and p300 are versatile transcriptional co-activators that play essential roles in
regulating a wide range of signaling pathways, including Wnt/β-catenin, p53, and HIF-1α …
regulating a wide range of signaling pathways, including Wnt/β-catenin, p53, and HIF-1α …
SM04755, a small‐molecule inhibitor of the Wnt pathway, as a potential topical treatment for tendinopathy
V Deshmukh, T Seo, AL O'Green… - Journal of …, 2021 - Wiley Online Library
The Wnt pathway is upregulated in tendinopathy, affecting inflammation and tenocyte
differentiation. Given its potential role in tendinopathy, this signaling pathway may be a …
differentiation. Given its potential role in tendinopathy, this signaling pathway may be a …
HSPA12A promotes c-Myc lactylation-mediated proliferation of tubular epithelial cells to facilitate renal functional recovery from kidney ischemia/reperfusion injury
Y Li, X Min, X Zhang, X Cao, Q Kong, Q Mao… - Cellular and Molecular …, 2024 - Springer
Proliferation of renal tubular epithelial cells (TEC) is essential for restoring tubular integrity
and thereby to support renal functional recovery from kidney ischemia/reperfusion (KI/R) …
and thereby to support renal functional recovery from kidney ischemia/reperfusion (KI/R) …
The involvement of branched-chain amino acids (BCAAs) in aromatic trihalogenated DBP exposure-induced kidney damage in mice
T Miao, M Li, T Shao, X Jiang, L Jiang, Q Zhou, Y Pan… - Chemosphere, 2022 - Elsevier
Disinfection by-products (DBPs) are inevitably generated in the process of disinfection.
Among them, aromatic halogenated DBPs, such as 2, 4, 6-trichlorophenol (TCP), 2, 4, 6 …
Among them, aromatic halogenated DBPs, such as 2, 4, 6-trichlorophenol (TCP), 2, 4, 6 …
An in vitro neurogenetics platform for precision disease modeling in the mouse
The power and scope of disease modeling can be markedly enhanced through the
incorporation of broad genetic diversity. The introduction of pathogenic mutations into a …
incorporation of broad genetic diversity. The introduction of pathogenic mutations into a …
Role of DNA damage in the progress of chronic tubule‑interstitial injury
L Sun, X Zhu, J Luo, C Wang… - Molecular medicine …, 2020 - spandidos-publications.com
Tubulointerstitial fibrosis (TIF) is a common final endpoint of chronic allograft nephropathy.
Over the years, several hypotheses have been developed to explain the progression of TIF …
Over the years, several hypotheses have been developed to explain the progression of TIF …