The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

TH Karlsen, N Sheron, S Zelber-Sagi, P Carrieri… - The Lancet, 2022 - thelancet.com
Executive summary Liver diseases have become a major health threat across Europe, and
the face of European hepatology is changing due to the cure of viral hepatitis C and the …

Contemporary epidemiology of chronic liver disease and cirrhosis

AM Moon, AG Singal, EB Tapper - Clinical Gastroenterology and …, 2020 - Elsevier
Background & Aims Accurate estimates for the contemporary burden of chronic liver disease
(CLD) are vital for setting clinical, research, and policy priorities. We aimed to review the …

Interventions to enhance testing, linkage to care, and treatment initiation for hepatitis C virus infection: a systematic review and meta-analysis

EB Cunningham, A Wheeler, B Hajarizadeh… - The lancet …, 2022 - thelancet.com
Background Despite the goal set by WHO to eliminate hepatitis C virus (HCV) as a public
health threat, uptake of HCV testing and treatment remains low. To achieve this target …

[PDF][PDF] 17‐beta hydroxysteroid dehydrogenase 13 is a hepatic retinol dehydrogenase associated with histological features of nonalcoholic fatty liver disease

Y Ma, OV Belyaeva, PM Brown, K Fujita, K Valles… - …, 2019 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. A
single‐nucleotide polymorphism (SNP), rs6834314, was associated with serum liver …

Direct-acting antiviral treatment for hepatitis C among people who use or inject drugs: a systematic review and meta-analysis

B Hajarizadeh, EB Cunningham, H Reid… - The lancet …, 2018 - thelancet.com
Background There are concerns around poorer response to direct-acting antiviral (DAA)
therapy for hepatitis C virus infection among people who use drugs. This systematic review …

Sofosbuvir and velpatasvir for hepatitis C virus infection in people with recent injection drug use (SIMPLIFY): an open-label, single-arm, phase 4, multicentre trial

J Grebely, O Dalgard, B Conway… - The lancet …, 2018 - thelancet.com
Background Despite revised guidelines that no longer exclude people who inject drugs
(PWID) from treatment for hepatitis C virus (HCV) infection, many clinicians are reluctant to …

Hepatitis C reinfection after successful antiviral treatment among people who inject drugs: A meta-analysis

B Hajarizadeh, EB Cunningham, H Valerio… - Journal of …, 2020 - Elsevier
Background & Aims HCV reinfection following successful treatment can compromise
treatment outcomes. This systematic review assessed the rate of HCV reinfection following …

Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology & Hepatology Commission

GS Cooke, I Andrieux-Meyer, TL Applegate… - The lancet …, 2019 - thelancet.com
Viral hepatitis is a major public health threat and a leading cause of death worldwide.
Annual mortality from viral hepatitis is similar to that of other major infectious diseases such …

Outcomes of treatment for hepatitis C in primary care, compared to hospital-based care: a randomized, controlled trial in people who inject drugs

AJ Wade, JS Doyle, E Gane, C Stedman… - Clinical Infectious …, 2020 - academic.oup.com
Abstract Background To achieve the World Health Organization hepatitis C virus (HCV)
elimination targets, it is essential to increase access to direct-acting antivirals (DAAs) …

We know DAA s work, so now what? Simplifying models of care to enhance the hepatitis C cascade

JV Lazarus, JM Pericàs, C Picchio… - Journal of internal …, 2019 - Wiley Online Library
Globally, some 71 million people are chronically infected with hepatitis C virus (HCV).
Marginalized populations, particularly people who inject drugs (PWID), have low testing …