Long-term efficacy and safety of anti-obesity treatment: where do we stand?

YJ Tak, SY Lee - Current obesity reports, 2021 - Springer
Abstract Purpose of Review As a chronic and relapsing disease, obesity impairs metabolism
and causes cardiovascular diseases. Although behavioral modification is important for the …

[HTML][HTML] Safety of semaglutide

MM Smits, DH Van Raalte - Frontiers in endocrinology, 2021 - frontiersin.org
The glucagon-like peptide-1 receptor agonist (GLP-1RA) semaglutide is the most recently
approved agent of this drug class, and the only GLP-1RA currently available as both …

Cohort profile: Risk evaluation of cancers in C hinese diabetic individuals: a longitudinal (REACTION) study (队列简介: 中国糖尿病患者肿瘤发生风险的纵向研究 …

Y Bi, J Lu, W Wang, Y Mu, J Zhao, C Liu… - Journal of …, 2014 - Wiley Online Library
摘要背景评估在中国人群中糖代谢异常(糖尿病及糖尿病早期) 是否与肿瘤风险增加相关,
并寻找糖代谢异常人群中影响肿瘤风险的因素. 方法2011‐2012 年间, 来自中国大陆地区25 …

GLP-1 receptor agonists and the risk of thyroid cancer

J Bezin, A Gouverneur, M Pénichon, C Mathieu… - Diabetes …, 2023 - Am Diabetes Assoc
OBJECTIVE To determine whether use of glucagon-like peptide 1 (GLP-1) receptor agonists
(RA) is associated with increased risk of thyroid cancer. RESEARCH DESIGN AND …

[HTML][HTML] Clinical use of DPP-4 inhibitors

B Gallwitz - Frontiers in endocrinology, 2019 - frontiersin.org
DPP-4 inhibitors were introduced for the treatment of type 2 diabetes in 2006. They stimulate
insulin secretion and inhibit glucagon secretion by elevating endogenous GLP-1 …

Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial

D Athauda, K Maclagan, SS Skene, M Bajwa-Joseph… - The Lancet, 2017 - thelancet.com
Background Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, has
neuroprotective effects in preclinical models of Parkinson's disease. We investigated …

Glucagon-like peptide 1 in health and disease

A Andersen, A Lund, FK Knop, T Vilsbøll - Nature Reviews …, 2018 - nature.com
In healthy individuals, the incretin hormone glucagon-like peptide 1 (GLP1) potentiates
insulin release and suppresses glucagon secretion in response to the ingestion of nutrients …

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

SE Kahn, ME Cooper, S Del Prato - The Lancet, 2014 - thelancet.com
Glucose metabolism is normally regulated by a feedback loop including islet β cells and
insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell …

Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer

PA Hart, MD Bellin, DK Andersen, D Bradley… - The lancet …, 2016 - thelancet.com
Diabetes mellitus is a group of diseases defined by persistent hyperglycaemia. Type 2
diabetes, the most prevalent form, is characterised initially by impaired insulin sensitivity and …

The epidemiology of pancreatitis and pancreatic cancer

D Yadav, AB Lowenfels - Gastroenterology, 2013 - Elsevier
Acute pancreatitis is one of the most frequent gastrointestinal causes of hospital admission
in the United States. Chronic pancreatitis, although lower in incidence, significantly reduces …