Recent advancements in the development of bioactive pyrazoline derivatives
Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …
been proven as a ubiquitous motif which is present in a number of pharmacologically …
A Medicinal Chemist's Perspective Towards Structure Activity Relationship of Heterocycle Based Anticancer Agents
Aim: This paper aims to describe the structure activity relationship of heterocyclic derivatives
with multi-targeted anticancer activity. Objectives: With the following goals in mind, this …
with multi-targeted anticancer activity. Objectives: With the following goals in mind, this …
Design and synthesis of carbothioamide/carboxamide-based pyrazoline analogs as potential anticancer agents: apoptosis, molecular docking, ADME assay, and DNA …
To discover anticancer drugs with novel structures and expand our research scope,
pyrazoline derivatives (3a–3l) were designed and synthesized through cyclization of …
pyrazoline derivatives (3a–3l) were designed and synthesized through cyclization of …
Pyrazoline analogs as potential anticancer agents and their apoptosis, molecular docking, MD simulation, DNA binding and antioxidant studies
N-formyl pyrazoline derivatives (3a–3l) were designed and synthesized via Michael addition
reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid …
reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid …
In vitro cytotoxicity and druglikeness of pyrazolines and pyridines bearing benzofuran moiety
A series of pyrazolines and pyridines bearing benzofuran moiety (M1–M10) were
synthesized for evaluation of their in vitro cytotoxicity against MCF-7 and HepG2 cell lines …
synthesized for evaluation of their in vitro cytotoxicity against MCF-7 and HepG2 cell lines …
PEO-chitosan nanofibers containing carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with pyrazoline for skin cancer treatment
AFC Rengifo, NM Stefanes, J Toigo, C Mendes… - European Polymer …, 2019 - Elsevier
Intact carboxymethyl-hexanoyl chitosan/dodecyl sulfate nanoparticles loaded with
pyrazoline H3TM04 were dispersed in biodegradable PEO-chitosan nanofiber mats …
pyrazoline H3TM04 were dispersed in biodegradable PEO-chitosan nanofiber mats …
Design, synthesis and biological evaluation of some new 2-Pyrazoline derivatives as potential anticancer agents
A new series of N-(4-(1-Phenyl-5-aryl-4, 5-dihydro-1H-pyrazol-3-yl) phenyl)-4-
substitutedbenzamide derivatives were designed and synthesized from new chalcone …
substitutedbenzamide derivatives were designed and synthesized from new chalcone …
Novel quinolinone–pyrazoline hybrids: Synthesis and evaluation of antioxidant and lipoxygenase inhibitory activity
I Kostopoulou, A Diassakou, E Kavetsou, E Kritsi… - Molecular Diversity, 2021 - Springer
The present project deals with the investigation of structure–activity relationship of several
quinolinone–chalcone and quinolinone–pyrazoline hybrids, in an effort to discover …
quinolinone–chalcone and quinolinone–pyrazoline hybrids, in an effort to discover …
Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation
Four new series of aromatic sulfamates were synthesized and investigated for the inhibition
of four human (h) isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2. 1.1), hCA I, II, IX …
of four human (h) isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2. 1.1), hCA I, II, IX …
β-Cyclodextrin as carrier of novel antioxidants: A structural and efficacy study
M Chatzidaki, I Kostopoulou, C Kourtesi… - Colloids and Surfaces A …, 2020 - Elsevier
Antioxidants are radical scavengers that have been proposed to be involved in many
pathological conditions, from aging to degenerative disorders. The aim of the present study …
pathological conditions, from aging to degenerative disorders. The aim of the present study …