Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important
functions in the regulation of growth and survival of certain cell types during embryonal …

The family of platelet-derived growth factors (PDGFs) plays a number of critical roles in
normal embryonic development, cellular differentiation, and response to tissue damage. Not …

Glioblastoma progression in its early stages remains poorly understood. Here, we transfer
PDGFB and genetic barcodes in mouse brain to initiate gliomagenesis and enable direct …

Glioblastoma (GBM) is one of the most lethal cancers, having a poor prognosis and a
median survival of only about 15 months with standard treatment (surgery, radiation, and …

The stem cell–determining transcription factor Sox2 is required for the maintenance of
normal neural stem cells. In this study, we investigated the requirement for Sox2 in neural …

A common mutation of the epidermal growth factor receptor (EGFR) in glioblastoma
multiforme (GBM) is an extracellular truncation known as the de2-7 EGFR (or EGFRvIII) …

BACKGROUND: Widespread infiltration of tumor cells into surrounding brain parenchyma is
a hallmark of malignant gliomas, but little data exist on the overall invasion pattern of tumor …

Ferroptosis and apoptosis are key cell‐death pathways implicated in several human
diseases including cancer. Ferroptosis is driven by iron‐dependent lipid peroxidation and …

This article discusses nonclinical and clinical data regarding the safety of recombinant
human platelet-derived growth factor-BB as a component of the Augment® Bone Graft …

The B-cell translocation gene-2 (BTG2), a p53-inducible gene, is suppressed in mammary
epithelial cells during gestation and lactation. In human breast cancer, decreased BTG2 …