[HTML][HTML] A metabolomic approach in search of neurobiomarkers of perinatal asphyxia: a review of the current literature

MJ Debuf, K Carkeek, F Piersigilli - Frontiers in pediatrics, 2021 - frontiersin.org
Perinatal asphyxia and the possible sequelae of hypoxic-ischemic encephalopathy (HIE),
are associated with high morbidity and mortality rates. The use of therapeutic hypothermia …

Hypoxic-Ischemic Brain Injury after Perinatal Asphyxia as a Possible Factor in the Pathology of Alzheimer's Disease

A Tarkowska - Exon Publications, 2021 - exonpublications.com
Perinatal asphyxia is a common pathological condition occurring worldwide in
approximately 4 million newborns annually. The result of this phenomenon is multi-organ …

[HTML][HTML] Urinary metabolic modulation in human participants residing in Siachen: a 1H NMR metabolomics approach

S Gandhi, V Chinnadurai, K Bhadra, I Gupta… - Scientific Reports, 2022 - nature.com
The main physiological challenge in high altitude environment is hypoxia which affects the
aerobic metabolism reducing the energy supply. These changes may further progress …

[HTML][HTML] Metabolomics investigation of post-mortem human pericardial fluid

A Chighine, M Stocchero, G Ferino… - International Journal of …, 2023 - Springer
Introduction Due to its peculiar anatomy and physiology, the pericardial fluid is a biological
matrix of particular interest in the forensic field. Despite this, the available literature has …

[HTML][HTML] Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model

E Locci, A Chighine, A Noto, G Ferino, A Baldi… - Scientific reports, 2021 - nature.com
The diagnosis of mechanical asphyxia remains one of the most difficult issues in forensic
pathology. Asphyxia ultimately results in cardiac arrest (CA) and, as there are no specific …

[HTML][HTML] The Urinary Metabolome of Newborns with Perinatal Complications

Y López-Hernández, V Lima-Rogel, R Mandal, J Zheng… - Metabolites, 2024 - mdpi.com
Maternal pathological conditions such as infections and chronic diseases, along with
unexpected events during labor, can lead to life-threatening perinatal outcomes. These …

[HTML][HTML] Posttreatment with ospemifene attenuates hypoxia-and ischemia-induced apoptosis in primary neuronal cells via selective modulation of estrogen receptors

BA Pietrzak, A Wnuk, K Przepiórska, A Łach… - Neurotoxicity …, 2023 - Springer
Stroke and perinatal asphyxia have detrimental effects on neuronal cells, causing millions of
deaths worldwide each year. Since currently available therapies are insufficient, there is an …

Slotting metabolomics into routine precision medicine

M Mussap, A Noto, C Piras, L Atzori… - Expert Review of …, 2021 - Taylor & Francis
Introduction Despite an impressive amount of metabolomics studies in animal models and
humans, most findings have not yet translated into the clinical setting, and the road ahead …

Pretreatment with mGluR2 or mGluR3 agonists reduces apoptosis induced by hypoxia‐ischemia in neonatal rat brains

E Bratek-Gerej, A Bronisz… - Oxidative Medicine …, 2021 - Wiley Online Library
Hypoxia‐ischemia (HI) in an immature brain results in energy depletion and excessive
glutamate release resulting in excitotoxicity and oxidative stress. An increase in reactive …

[HTML][HTML] Urine NMR metabolomics profile of preterm infants with necrotizing enterocolitis over the first two months of life: a pilot longitudinal case-control study

JC Picaud, A De Magistris, M Mussap… - Frontiers in Molecular …, 2021 - frontiersin.org
Objective: To investigate changes in the urine metabolome of very low birth weight preterm
newborns with necrotizing enterocolitis (NEC) and feed intolerance, we conducted a …