[HTML][HTML] A metabolomic approach in search of neurobiomarkers of perinatal asphyxia: a review of the current literature
MJ Debuf, K Carkeek, F Piersigilli - Frontiers in pediatrics, 2021 - frontiersin.org
Perinatal asphyxia and the possible sequelae of hypoxic-ischemic encephalopathy (HIE),
are associated with high morbidity and mortality rates. The use of therapeutic hypothermia …
are associated with high morbidity and mortality rates. The use of therapeutic hypothermia …
Hypoxic-Ischemic Brain Injury after Perinatal Asphyxia as a Possible Factor in the Pathology of Alzheimer's Disease
A Tarkowska - Exon Publications, 2021 - exonpublications.com
Perinatal asphyxia is a common pathological condition occurring worldwide in
approximately 4 million newborns annually. The result of this phenomenon is multi-organ …
approximately 4 million newborns annually. The result of this phenomenon is multi-organ …
[HTML][HTML] Urinary metabolic modulation in human participants residing in Siachen: a 1H NMR metabolomics approach
S Gandhi, V Chinnadurai, K Bhadra, I Gupta… - Scientific Reports, 2022 - nature.com
The main physiological challenge in high altitude environment is hypoxia which affects the
aerobic metabolism reducing the energy supply. These changes may further progress …
aerobic metabolism reducing the energy supply. These changes may further progress …
[HTML][HTML] Metabolomics investigation of post-mortem human pericardial fluid
A Chighine, M Stocchero, G Ferino… - International Journal of …, 2023 - Springer
Introduction Due to its peculiar anatomy and physiology, the pericardial fluid is a biological
matrix of particular interest in the forensic field. Despite this, the available literature has …
matrix of particular interest in the forensic field. Despite this, the available literature has …
[HTML][HTML] Metabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model
The diagnosis of mechanical asphyxia remains one of the most difficult issues in forensic
pathology. Asphyxia ultimately results in cardiac arrest (CA) and, as there are no specific …
pathology. Asphyxia ultimately results in cardiac arrest (CA) and, as there are no specific …
[HTML][HTML] The Urinary Metabolome of Newborns with Perinatal Complications
Maternal pathological conditions such as infections and chronic diseases, along with
unexpected events during labor, can lead to life-threatening perinatal outcomes. These …
unexpected events during labor, can lead to life-threatening perinatal outcomes. These …
[HTML][HTML] Posttreatment with ospemifene attenuates hypoxia-and ischemia-induced apoptosis in primary neuronal cells via selective modulation of estrogen receptors
BA Pietrzak, A Wnuk, K Przepiórska, A Łach… - Neurotoxicity …, 2023 - Springer
Stroke and perinatal asphyxia have detrimental effects on neuronal cells, causing millions of
deaths worldwide each year. Since currently available therapies are insufficient, there is an …
deaths worldwide each year. Since currently available therapies are insufficient, there is an …
Slotting metabolomics into routine precision medicine
Introduction Despite an impressive amount of metabolomics studies in animal models and
humans, most findings have not yet translated into the clinical setting, and the road ahead …
humans, most findings have not yet translated into the clinical setting, and the road ahead …
Pretreatment with mGluR2 or mGluR3 agonists reduces apoptosis induced by hypoxia‐ischemia in neonatal rat brains
E Bratek-Gerej, A Bronisz… - Oxidative Medicine …, 2021 - Wiley Online Library
Hypoxia‐ischemia (HI) in an immature brain results in energy depletion and excessive
glutamate release resulting in excitotoxicity and oxidative stress. An increase in reactive …
glutamate release resulting in excitotoxicity and oxidative stress. An increase in reactive …
[HTML][HTML] Urine NMR metabolomics profile of preterm infants with necrotizing enterocolitis over the first two months of life: a pilot longitudinal case-control study
Objective: To investigate changes in the urine metabolome of very low birth weight preterm
newborns with necrotizing enterocolitis (NEC) and feed intolerance, we conducted a …
newborns with necrotizing enterocolitis (NEC) and feed intolerance, we conducted a …