The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …

Synthetic biology applies genetic tools to engineer living cells and organisms analogous to
the programming of machines. In materials synthetic biology, engineering principles from …

The genome is a sequence that encodes the DNA, RNA, and proteins that orchestrate an
organism's function. We present Evo, a long-context genomic foundation model with a …

Transcription rates are regulated by the interactions between RNA polymerase, sigma factor,
and promoter DNA sequences in bacteria. However, it remains unclear how non-canonical …

Abstract Design of de novo synthetic regulatory DNA is a promising avenue to control gene
expression in biotechnology and medicine. Using mutagenesis typically requires screening …

Cells interact with their environment, communicate among themselves, track time and make
decisions through functions controlled by natural regulatory genetic circuits consisting of …

Engineering the genetic code of an organism has been proposed to provide a firewall from
natural ecosystems by preventing viral infections and gene transfer,,,,–. However, numerous …

Filamentous fungi drive carbon and nutrient cycling across our global ecosystems, through
its interactions with growing and decaying flora and their constituent microbiomes. The …

Synthetic biology continues to progress by relying on more robust tools for transcriptional
control, of which promoters are the most fundamental component. Numerous studies have …

Quorum sensing (QS) is a ubiquitous cell–cell communication mechanism that can be
employed to autonomously and dynamically control metabolic fluxes. However, since the …