Structural and functional comparison of magnesium transporters throughout evolution

GAC Franken, MA Huynen, LA Martínez-Cruz… - Cellular and Molecular …, 2022 - Springer
Abstract Magnesium (Mg2+) is the most prevalent divalent intracellular cation. As co-factor in
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …

Mono-and sesquiterpenes as a starting platform for the development of antiviral drugs

OI Yarovaya, NF Salakhutdinov - Russian Chemical Reviews, 2021 - iopscience.iop.org
The revies focuses on low-molecular-weight plant metabolites (mono-and sesquiterpenes)
exhibiting antiviral activity. Data on antiviral action of both essential oils and plant extracts …

Ultrasound modulates ion channel currents

J Kubanek, J Shi, J Marsh, D Chen, C Deng, J Cui - Scientific reports, 2016 - nature.com
Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in
animals and humans, but the mechanism of this effect is unknown. It has been hypothesized …

A survey of biological building blocks for synthetic molecular communication systems

CA Söldner, E Socher, V Jamali… - … Surveys & Tutorials, 2020 - ieeexplore.ieee.org
Synthetic molecular communication (MC) is a new communication engineering paradigm
which is expected to enable revolutionary applications such as smart drug delivery and real …

Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Š Gubič, LA Hendrickx, Ž Toplak… - Medicinal research …, 2021 - Wiley Online Library
Abstract The KV1. 3 voltage‐gated potassium ion channel is involved in many physiological
processes both at the plasma membrane and in the mitochondria, chiefly in the immune and …

The “www” of Xenopus laevis Oocytes: The Why, When, What of Xenopus laevis Oocytes in Membrane Transporters Research

M Bhatt, A Di Iacovo, T Romanazzi, C Roseti… - Membranes, 2022 - mdpi.com
After 50 years, the heterologous expression of proteins in Xenopus laevis oocytes is still
essential in many research fields. New approaches and revised protocols, but also classical …

[HTML][HTML] Advances in our understanding of nematode ion channels as potential anthelmintic targets

S Choudhary, SS Kashyap, RJ Martin… - International Journal for …, 2022 - Elsevier
Ion channels are specialized multimeric proteins that underlie cell excitability. These
channels integrate with a variety of neuromuscular and biological functions. In nematodes …

Antioxidative and analgesic effects of naringin through selective inhibition of transient receptor potential vanilloid member 1

S Eom, BB Lee, S Lee, Y Park, HD Yeom, TH Kim… - Antioxidants, 2021 - mdpi.com
Transient receptor potential vanilloid member 1 (TRPV1) is activated in response to
capsaicin, protons, temperature, and free reactive oxygen species (ROS) released from …

Drug discovery on natural products: from ion channels to nAChRs, from nature to libraries, from analytics to assays

RA Otvos, KBM Still, GW Somsen… - … Life Sciences R&D, 2019 - journals.sagepub.com
Natural extracts are complex mixtures that may be rich in useful bioactive compounds and
therefore are attractive sources for new leads in drug discovery. This review describes drug …

Electrophysiological characterization of a diverse group of sugar transporters from Trichoderma reesei

S Havukainen, J Pujol-Giménez, M Valkonen… - Scientific reports, 2021 - nature.com
Trichoderma reesei is an ascomycete fungus known for its capability to secrete high
amounts of extracellular cellulose-and hemicellulose-degrading enzymes. These enzymes …