Structural and functional comparison of magnesium transporters throughout evolution
GAC Franken, MA Huynen, LA Martínez-Cruz… - Cellular and Molecular …, 2022 - Springer
Abstract Magnesium (Mg2+) is the most prevalent divalent intracellular cation. As co-factor in
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …
Mono-and sesquiterpenes as a starting platform for the development of antiviral drugs
OI Yarovaya, NF Salakhutdinov - Russian Chemical Reviews, 2021 - iopscience.iop.org
The revies focuses on low-molecular-weight plant metabolites (mono-and sesquiterpenes)
exhibiting antiviral activity. Data on antiviral action of both essential oils and plant extracts …
exhibiting antiviral activity. Data on antiviral action of both essential oils and plant extracts …
Ultrasound modulates ion channel currents
Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in
animals and humans, but the mechanism of this effect is unknown. It has been hypothesized …
animals and humans, but the mechanism of this effect is unknown. It has been hypothesized …
A survey of biological building blocks for synthetic molecular communication systems
Synthetic molecular communication (MC) is a new communication engineering paradigm
which is expected to enable revolutionary applications such as smart drug delivery and real …
which is expected to enable revolutionary applications such as smart drug delivery and real …
Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges
Š Gubič, LA Hendrickx, Ž Toplak… - Medicinal research …, 2021 - Wiley Online Library
Abstract The KV1. 3 voltage‐gated potassium ion channel is involved in many physiological
processes both at the plasma membrane and in the mitochondria, chiefly in the immune and …
processes both at the plasma membrane and in the mitochondria, chiefly in the immune and …
The “www” of Xenopus laevis Oocytes: The Why, When, What of Xenopus laevis Oocytes in Membrane Transporters Research
M Bhatt, A Di Iacovo, T Romanazzi, C Roseti… - Membranes, 2022 - mdpi.com
After 50 years, the heterologous expression of proteins in Xenopus laevis oocytes is still
essential in many research fields. New approaches and revised protocols, but also classical …
essential in many research fields. New approaches and revised protocols, but also classical …
[HTML][HTML] Advances in our understanding of nematode ion channels as potential anthelmintic targets
Ion channels are specialized multimeric proteins that underlie cell excitability. These
channels integrate with a variety of neuromuscular and biological functions. In nematodes …
channels integrate with a variety of neuromuscular and biological functions. In nematodes …
Antioxidative and analgesic effects of naringin through selective inhibition of transient receptor potential vanilloid member 1
S Eom, BB Lee, S Lee, Y Park, HD Yeom, TH Kim… - Antioxidants, 2021 - mdpi.com
Transient receptor potential vanilloid member 1 (TRPV1) is activated in response to
capsaicin, protons, temperature, and free reactive oxygen species (ROS) released from …
capsaicin, protons, temperature, and free reactive oxygen species (ROS) released from …
Drug discovery on natural products: from ion channels to nAChRs, from nature to libraries, from analytics to assays
RA Otvos, KBM Still, GW Somsen… - … Life Sciences R&D, 2019 - journals.sagepub.com
Natural extracts are complex mixtures that may be rich in useful bioactive compounds and
therefore are attractive sources for new leads in drug discovery. This review describes drug …
therefore are attractive sources for new leads in drug discovery. This review describes drug …
Electrophysiological characterization of a diverse group of sugar transporters from Trichoderma reesei
S Havukainen, J Pujol-Giménez, M Valkonen… - Scientific reports, 2021 - nature.com
Trichoderma reesei is an ascomycete fungus known for its capability to secrete high
amounts of extracellular cellulose-and hemicellulose-degrading enzymes. These enzymes …
amounts of extracellular cellulose-and hemicellulose-degrading enzymes. These enzymes …