Immunoinformatics and vaccine development: an overview

AN Oli, WO Obialor, MO Ifeanyichukwu… - ImmunoTargets and …, 2020 - Taylor & Francis
The use of vaccines have resulted in a remarkable improvement in global health. It has
saved several lives, reduced treatment costs and raised the quality of animal and human …

Helicobacter pylori BabA–SabA Key Roles in the Adherence Phase: The Synergic Mechanism for Successful Colonization and Disease Development

D Doohan, YAA Rezkitha, LA Waskito, Y Yamaoka… - Toxins, 2021 - mdpi.com
Helicobacter pylori is a pathogenic microorganism that successfully inhabits the human
stomach, colonizing it by producing several virulence factors responsible for preventing host …

Identification of vaccine targets in pathogens and design of a vaccine using computational approaches

K Rawal, R Sinha, BA Abbasi, A Chaudhary, SK Nath… - Scientific reports, 2021 - nature.com
Antigen identification is an important step in the vaccine development process.
Computational approaches including deep learning systems can play an important role in …

Pan-vaccinomics approach towards a universal vaccine candidate against WHO priority pathogens to address growing global antibiotic resistance

S Ismail, F Shahid, A Khan, S Bhatti, S Ahmad… - Computers in Biology …, 2021 - Elsevier
Antimicrobial resistance (AMR) in bacterial pathogens is a major global distress. Due to the
slow progress of antibiotics development and the fast pace of resistance acquisition, there is …

In silico design and analyses of a multi-epitope vaccine against Crimean-Congo hemorrhagic fever virus through reverse vaccinology and immunoinformatics …

AA Omoniyi, SS Adebisi, SA Musa, JO Nzalak… - Scientific Reports, 2022 - nature.com
Abstract Crimean Congo Hemorrhagic Fever virus (CCHFV) is a deadly human pathogen
that causes an emerging zoonotic disease with a broad geographic spread, especially in …

Bioinformatics analysis and consistency verification of a novel tuberculosis vaccine candidate HP13138PB

P Cheng, F Jiang, G Wang, J Wang, Y Xue… - Frontiers in …, 2023 - frontiersin.org
Background With the increasing incidence of tuberculosis (TB) and the shortcomings of
existing TB vaccines to prevent TB in adults, new TB vaccines need to be developed to …

An overview of in silico vaccine design against different pathogens and cancer

K Kardani, A Bolhassani, A Namvar - Expert Review of Vaccines, 2020 - Taylor & Francis
Introduction Due to overcome the hardness of the vaccine design, computational
vaccinology is emerging widely. Prediction of T cell and B cell epitopes, antigen processing …

In silico design of a multi-epitope vaccine against HPV16/18

S Sanami, M Rafieian-Kopaei, KA Dehkordi… - BMC …, 2022 - Springer
Background Cervical cancer is the fourth most common cancer affecting women and is
caused by human Papillomavirus (HPV) infections that are sexually transmitted. There are …

PP19128R, a Multiepitope Vaccine Designed to Prevent Latent Tuberculosis Infection, Induced Immune Responses In Silico and In Vitro Assays

F Jiang, C Peng, P Cheng, J Wang, J Lian, W Gong - Vaccines, 2023 - mdpi.com
Background: Latent tuberculosis infection (LTBI) is the primary source of active tuberculosis
(ATB), but a preventive vaccine against LTBI is lacking. Methods: In this study, dominant …

[HTML][HTML] In silico design of a promiscuous chimeric multi-epitope vaccine against Mycobacterium tuberculosis

BT Andongma, Y Huang, F Chen, Q Tang… - Computational and …, 2023 - Elsevier
Tuberculosis (TB) is a global health threat, killing approximately 1.5 million people each
year. The eradication of Mycobacterium tuberculosis, the main causative agent of TB, is …