Engagement of the T cell antigen receptor (TCR) leads to a complex series of molecular
changes at the plasma membrane, in the cytoplasm, and at the nucleus that lead ultimately …

▪ Abstract In B lymphocytes, a signaling complex that contributes to cell fate decisions is the
B cell antigen receptor (BCR). Data from knockout experiments in cell lines and mice have …

The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR
engagement. Phosphorylated LAT binds many critical signaling molecules. The central role …

The Ras signaling pathway plays a critical role in thymopoiesis and T cell activation, but the
mechanism of Ras regulation is controversial. At least one mode of Ras regulation in T cells …

Abstract Background: The adaptor protein Gads is a Grb2-related protein originally identified
on the basis of its interaction with the tyrosine-phosphorylated form of the docking protein …

The adaptor molecule LAT (l inker for a ctivation of T cells) is a palmitoylated integral
membrane protein that localizes to the glycolipid-enriched microdomains in the plasma …

Accumulating evidence indicates that the interdomain B regions of ZAP‐70 and Syk play
pivotal roles in the coupling of T‐cell antigen receptor (TCR) stimulation to the activation of …

During the past year, major progress has been made in understanding proximal TCR signal-
transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP …

Host defense against pathogenic microbes requires dramatically different responses,
depending on the character of the pathogen and on the tissue under attack. Central to the …

The antigen receptors on T and B lymphocytes (TCR and BCR) are multimeric complexes
composed of a receptor module associated with various signaling proteins (CD3 γδε, and …